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Updated: Nov 11, 2025
Establishment of a Clinic-based Biorepository
Published on: May 29, 2017
Establishing a reproductive biorepository for basic and translational research: experience developing the
Samantha B Schon1, Nicholas Raja2, Min Xu3
1Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA. sschon@mail.med.umich.edu.
Purpose:
To report experience designing and establishing a reproductive registry and sample biorepository and to describe initial subject characteristics and biospecimens.
Methods:
Beginning in December 2017, patients presenting for reproductive care at the University of Michigan were approached for study enrollment. Following consent, subjects completed detailed reproductive and health questionnaires. A variety of reproductive specimens and tissues were collected and processed for multiple downstream applications.
Results:
Subject enrollment began in December of 2017. There are currently 1798 subjects enrolled. Female participants report a variety of reproductive disorders. Available samples include semen, sperm, follicular fluid, granulosa cells, immature oocytes, ovarian and uterine tissue, and blood samples.
Conclusion:
We report the successful establishment of a reproductive registry and sample biorepository. Furthermore, we describe methods for collection and storage of a variety of reproductive tissue processed for multiple downstream translational applications.
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