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Updated: Nov 11, 2025

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model
07:56

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model

Published on: January 10, 2025

882

Retraction

    Journal of Cellular Biochemistry
    |March 31, 2021
    PubMed

    Insights

    The long non-coding RNA HULC was found to promote osteosarcoma progression. Its knockdown inhibited tumor growth and spread by interacting with microRNA-122.

    Area of Science:

    • Molecular Biology
    • Oncology
    • Biochemistry

    Context:

    • Osteosarcoma is a primary bone malignancy with limited effective treatments.
    • Long non-coding RNAs (lncRNAs) are increasingly recognized for their roles in cancer.
    • The specific role of lncRNA HULC in osteosarcoma pathogenesis requires further elucidation.

    Purpose:

    • To investigate the function of lncRNA HULC in osteosarcoma.
    • To explore the underlying molecular mechanism involving microRNA-122 (miR-122).

    Summary:

    • Knockdown of lncRNA HULC significantly inhibited osteosarcoma cell proliferation, migration, and invasion.
    • HULC acts as a molecular sponge for miR-122, thereby regulating its activity.
    • The findings suggested that HULC promotes osteosarcoma progression via the miR-122 pathway.

    Impact:

    • This study aimed to identify lncRNA HULC as a potential therapeutic target for osteosarcoma.
    • Understanding the HULC/miR-122 interaction could offer new strategies for osteosarcoma treatment.

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