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Kidney Injury Molecule-1 Is Associated with Contrast-Induced Nephropathy in Elderly Patients with Non-STEMI

Mustafa Ahmet Huyut1

  • 1Yeni Yuzyil University, Faculdade de Medicina, Departamento de Cardiologia, Istambul - Turquia.

Arquivos Brasileiros De Cardiologia
|March 31, 2021
PubMed

Insights

Serum kidney injury molecule-1 (KIM-1) and Mehran score predict contrast-induced nephropathy (CIN) in elderly patients with non-ST-segment elevation myocardial infarction (NSTEMI). Higher KIM-1 levels correlate with increased risk of major adverse cardiovascular events (MACE) post-procedure.

Area of Science:

  • Nephrology
  • Cardiology
  • Biomarkers

Background:

  • Contrast-induced nephropathy (CIN) is linked to major adverse cardiovascular events (MACE).
  • Oxidative stress mechanisms are implicated in the development of CIN.

Purpose of the Study:

  • To investigate the association between serum kidney injury molecule-1 (KIM-1) levels and CIN.
  • To evaluate CIN predictors in elderly patients with non-ST-segment elevation myocardial infarction (NSTEMI).

Main Methods:

  • A cohort of 758 NSTEMI patients undergoing percutaneous coronary intervention (PCI) was studied.
  • 15 patients developed CIN, compared to a matched control group of 104.
  • Serum KIM-1, Mehran score, and clinical outcomes were assessed at baseline and up to 72 hours, with one-year follow-up.

Main Results:

  • CIN occurred in 12.60% of patients.
  • Serum KIM-1 and Mehran scores were significantly higher in the CIN group (p < 0.001 and p = 0.001, respectively).
  • Major adverse cardiovascular events (MACE) were significantly more frequent in the CIN group (46.70% vs. 11.50%, p = 0.001).

Conclusions:

  • Baseline serum KIM-1 concentration and Mehran score are independent predictors of CIN in elderly NSTEMI patients.
  • The CIN group experienced significantly higher rates of mortality, cardiovascular death, myocardial reinfarction, stroke, and MACE at one-year follow-up.
Abstract

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