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Adaptive gene misregulation.

Andreas Wagner1,2,3

  • 1Department of Evolutionary Biology and Environmental Studies, University of Zurich, Zurich, CH-8057, Switzerland.

Genetics
|March 31, 2021
PubMed
Summary
This summary is machine-generated.

Gene misregulation, caused by DNA mutations, can be adaptive in new environments. Mathematical models and simulations show conditions where this evolutionary adaptation is likely, highlighting misregulation

Keywords:
adaptationevolvabilityexpressionregulation

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Area of Science:

  • Evolutionary biology
  • Genetics
  • Molecular biology

Background:

  • Gene expression is crucial for evolutionary adaptation.
  • Misregulation of gene expression can lead to maladaptation.
  • DNA mutations altering transcription factor binding sites cause misregulation and regulatory crosstalk.

Purpose of the Study:

  • To derive mathematical expressions defining conditions for adaptive misregulation.
  • To investigate when these conditions are met using empirical data and simulations.
  • To provide a framework for understanding misregulation's role in adaptation.

Main Methods:

  • Derivation of mathematical expressions for adaptive misregulation.
  • Analysis of empirical data from RNA sequencing and protein-binding microarrays.
  • Population genetic simulations incorporating genome evolution.

Main Results:

  • Identified conditions under which gene misregulation can be adaptive.
  • Demonstrated that these conditions can be met in realistic scenarios.
  • Showed variability in these circumstances across organisms and environments.

Conclusions:

  • Misregulation, like mutation, can drive Darwinian evolution.
  • Further theoretical and empirical work can clarify misregulation's adaptive role.
  • The study offers a framework for studying gene misregulation in adaptation.