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Conferring Ti-Based MOFs with Defects for Enhanced Sonodynamic Cancer Therapy.

Shuang Liang1,2, Xiao Xiao1,2, Lixin Bai3

  • 1State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.

Advanced Materials (Deerfield Beach, Fla.)
|April 1, 2021
PubMed
Summary

Researchers developed a novel defect-rich titanium-based metal-organic framework (D-MOF(Ti)) for enhanced sonodynamic therapy (SDT). This material shows superior reactive oxygen species generation and synergistic chemodynamic therapy effects for cancer treatment with minimal toxicity.

Keywords:
Ti-based metal-organic frameworkschemodynamic therapydefectssonodynamic therapy

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Development of efficient, multifunctional, and biocompatible sonosensitizers is crucial for sonodynamic therapy (SDT).
  • Existing sonosensitizers often face limitations in efficiency and biocompatibility.
  • Titanium dioxide (TiO2) is a commonly used but improvable sonosensitizer.

Purpose of the Study:

  • To construct a defect-rich Ti-based metal-organic framework (D-MOF(Ti)) for enhanced sonodynamic therapy (SDT).
  • To investigate the synergistic potential of D-MOF(Ti) in combined sonodynamic and chemodynamic therapy for cancer treatment.
  • To evaluate the biocompatibility and biodegradability of the novel sonosensitizer.

Main Methods:

  • Simple construction of a defect-rich Ti-based metal-organic framework (D-MOF(Ti)).
  • Evaluation of sonosensitizing effect under ultrasound (US) irradiation, measuring reactive oxygen species (ROS) yield.
  • Assessment of Fenton-like activity for chemodynamic therapy and evaluation of synergistic effects with SDT.
  • Investigation of D-MOF(Ti) biocompatibility and metabolic degradation.

Main Results:

  • D-MOF(Ti) demonstrated a superior reactive oxygen species (ROS) yield compared to TiO2 under ultrasound irradiation, attributed to its narrow bandgap and improved electron-hole separation.
  • The presence of Ti3+ ions in D-MOF(Ti) enabled significant Fenton-like activity, facilitating chemodynamic therapy.
  • Ultrasound irradiation synergistically enhanced the Fenton-like reaction, leading to improved oncotherapy outcomes.
  • D-MOF(Ti) exhibited biocompatibility and was found to be degradable and metabolizable, minimizing off-target toxicity.

Conclusions:

  • A novel Ti-based metal-organic framework (D-MOF(Ti)) was successfully developed as a highly efficient sonosensitizer.
  • D-MOF(Ti) offers synergistic sonodynamic and chemodynamic therapeutic effects for cancer treatment.
  • This Ti-familial sonosensitizer holds great potential for advanced oncotherapy due to its efficacy, biocompatibility, and biodegradability.