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Conferring Ti-Based MOFs with Defects for Enhanced Sonodynamic Cancer Therapy
Shuang Liang1,2, Xiao Xiao1,2, Lixin Bai3
1State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
Researchers developed a novel defect-rich titanium-based metal-organic framework (D-MOF(Ti)) for enhanced sonodynamic therapy (SDT). This material shows superior reactive oxygen species generation and synergistic chemodynamic therapy effects for cancer treatment with minimal toxicity.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Development of efficient, multifunctional, and biocompatible sonosensitizers is crucial for sonodynamic therapy (SDT).
- Existing sonosensitizers often face limitations in efficiency and biocompatibility.
- Titanium dioxide (TiO2) is a commonly used but improvable sonosensitizer.
Purpose of the Study:
- To construct a defect-rich Ti-based metal-organic framework (D-MOF(Ti)) for enhanced sonodynamic therapy (SDT).
- To investigate the synergistic potential of D-MOF(Ti) in combined sonodynamic and chemodynamic therapy for cancer treatment.
- To evaluate the biocompatibility and biodegradability of the novel sonosensitizer.
Main Methods:
- Simple construction of a defect-rich Ti-based metal-organic framework (D-MOF(Ti)).
- Evaluation of sonosensitizing effect under ultrasound (US) irradiation, measuring reactive oxygen species (ROS) yield.
- Assessment of Fenton-like activity for chemodynamic therapy and evaluation of synergistic effects with SDT.
- Investigation of D-MOF(Ti) biocompatibility and metabolic degradation.
Main Results:
- D-MOF(Ti) demonstrated a superior reactive oxygen species (ROS) yield compared to TiO2 under ultrasound irradiation, attributed to its narrow bandgap and improved electron-hole separation.
- The presence of Ti3+ ions in D-MOF(Ti) enabled significant Fenton-like activity, facilitating chemodynamic therapy.
- Ultrasound irradiation synergistically enhanced the Fenton-like reaction, leading to improved oncotherapy outcomes.
- D-MOF(Ti) exhibited biocompatibility and was found to be degradable and metabolizable, minimizing off-target toxicity.
Conclusions:
- A novel Ti-based metal-organic framework (D-MOF(Ti)) was successfully developed as a highly efficient sonosensitizer.
- D-MOF(Ti) offers synergistic sonodynamic and chemodynamic therapeutic effects for cancer treatment.
- This Ti-familial sonosensitizer holds great potential for advanced oncotherapy due to its efficacy, biocompatibility, and biodegradability.
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