Related Experiment Video

Updated: Nov 10, 2025

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
08:27

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

Published on: January 7, 2019

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TRPC5 in cardiovascular diseases

Sheng-Li Du1, Zeng-Qin Jia2, Jiu-Chang Zhong1

  • 1Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, 100020 Beijing, P. R. China.

Reviews in Cardiovascular Medicine
|April 1, 2021
PubMed

Insights

Transient receptor potential channel 5 (TRPC5) plays a key role in cardiovascular diseases (CVD) by influencing calcium dynamics. Blocking TRPC5 shows potential for treating CVD and related conditions like atherosclerosis.

Area of Science:

  • Cardiovascular Biology
  • Molecular Medicine
  • Channel Physiology

Background:

  • Cardiovascular diseases (CVD) are a leading global cause of mortality and morbidity.
  • Atherosclerosis (AS), a primary driver of CVD, involves chronic inflammation and complex cellular mechanisms.
  • Calcium (Ca2+) dynamics in endothelial cells (ECs) and smooth muscle cells (SMCs) are critical in CVD pathogenesis.

Purpose of the Study:

  • To review the significant roles of Transient Receptor Potential channel 5 (TRPC5) in cardiovascular health.
  • To evaluate TRPC5 as a potential therapeutic target for treating CVD and associated diseases.

Main Methods:

  • Literature review focusing on TRPC5's involvement in cardiovascular disorders.
  • Analysis of TRPC5's mechanisms, including calcium homeostasis, oxidative stress, and apoptosis.
  • Examination of TRPC5 expression in relevant cell types like ECs and SMCs.

Main Results:

  • TRPC5 is implicated in various cardiovascular conditions, including AS, cardiac hypertrophy, and blood pressure regulation.
  • TRPC5's function is linked to critical cellular processes such as calcium regulation, oxidative stress, and apoptosis.
  • Human TRPC5 is expressed in key cardiovascular cells (ECs, SMCs) and other organs.

Conclusions:

  • TRPC5 is a significant factor in the development and progression of cardiovascular diseases.
  • Targeting TRPC5 presents a promising therapeutic strategy for managing CVD and related pathologies.

Keywords:
AtherosclerosisCardiovascular diseaseReviewTRPC5

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