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Related Concept Videos

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Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Coronary Artery Disease I: Introduction01:30

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Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
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Psychoneuroimmunology: Cardiovascular Disease01:27

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Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
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Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of...
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Related Experiment Video

Updated: Nov 10, 2025

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
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Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

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TRPC5 in cardiovascular diseases.

Sheng-Li Du1, Zeng-Qin Jia2, Jiu-Chang Zhong1

  • 1Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, 100020 Beijing, P. R. China.

Reviews in Cardiovascular Medicine
|April 1, 2021
PubMed
Summary
This summary is machine-generated.

Transient receptor potential channel 5 (TRPC5) plays a key role in cardiovascular diseases (CVD) by influencing calcium dynamics. Blocking TRPC5 shows potential for treating CVD and related conditions like atherosclerosis.

Keywords:
AtherosclerosisCardiovascular diseaseReviewTRPC5

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Area of Science:

  • Cardiovascular Biology
  • Molecular Medicine
  • Channel Physiology

Background:

  • Cardiovascular diseases (CVD) are a leading global cause of mortality and morbidity.
  • Atherosclerosis (AS), a primary driver of CVD, involves chronic inflammation and complex cellular mechanisms.
  • Calcium (Ca2+) dynamics in endothelial cells (ECs) and smooth muscle cells (SMCs) are critical in CVD pathogenesis.

Purpose of the Study:

  • To review the significant roles of Transient Receptor Potential channel 5 (TRPC5) in cardiovascular health.
  • To evaluate TRPC5 as a potential therapeutic target for treating CVD and associated diseases.

Main Methods:

  • Literature review focusing on TRPC5's involvement in cardiovascular disorders.
  • Analysis of TRPC5's mechanisms, including calcium homeostasis, oxidative stress, and apoptosis.
  • Examination of TRPC5 expression in relevant cell types like ECs and SMCs.

Main Results:

  • TRPC5 is implicated in various cardiovascular conditions, including AS, cardiac hypertrophy, and blood pressure regulation.
  • TRPC5's function is linked to critical cellular processes such as calcium regulation, oxidative stress, and apoptosis.
  • Human TRPC5 is expressed in key cardiovascular cells (ECs, SMCs) and other organs.

Conclusions:

  • TRPC5 is a significant factor in the development and progression of cardiovascular diseases.
  • Targeting TRPC5 presents a promising therapeutic strategy for managing CVD and related pathologies.