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Interaction between β-lactam antibiotic and phosphorus-accumulating organisms.

Rong Huang1, Jing Lan1, Chaoguo Zhan1,2

  • 1School of Environmental Science and Safety Engineering, Tianjin Key Laboratory of Hazardous Waste Safety Disposal and Recycling Technology, Tianjin University of Technology, Tianjin, 300384, China.

Environmental Science and Pollution Research International
|April 1, 2021
PubMed
Summary

Certain β-lactam antibiotics, like amoxicillin and aztreonam, can enhance phosphorus removal by phosphorus-accumulating organisms (PAOs), while cefoperazone shows inhibitory effects. This study investigates antibiotic impacts on PAOs and their environmental fate.

Keywords:
Degradation modesIntracellular polymersPhosphorus removal ratePhosphorus-accumulating organisms (PAOs)Toxic effectβ-Lactam antibiotics

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Area of Science:

  • Environmental Microbiology
  • Biotechnology
  • Ecotoxicology

Background:

  • β-Lactam antibiotics are widely used clinically and detected in the environment.
  • Phosphorus-accumulating organisms (PAOs) are crucial for enhanced biological phosphorus removal (EBPR).

Purpose of the Study:

  • To investigate the interaction mechanisms between β-lactam antibiotics (amoxicillin, aztreonam, cefoperazone) and PAOs.
  • To comprehensively analyze the effects of these antibiotics on PAOs' phosphorus removal, intracellular polymer synthesis, toxicity, and the antibiotics' environmental fate.

Main Methods:

  • Exposure of PAOs to amoxicillin, aztreonam, and cefoperazone at 10 mg/L.
  • Analysis of phosphorus removal rates, intracellular polyphosphate (poly-P) synthesis, and antibiotic degradation.
  • Bacteriostatic tests to determine antibiotic toxicity to PAOs.

Main Results:

  • Amoxicillin and aztreonam increased PAO phosphorus removal rates by 19.21% and 15.75%, respectively.
  • Cefoperazone exhibited an inhibitory effect on phosphorus removal efficiency.
  • All three antibiotics promoted poly-P synthesis in PAOs during the aerobic stage.
  • Antibiotic degradation rates followed the order: amoxicillin > aztreonam > cefoperazone.
  • Antibiotic toxicity order was: cefoperazone > aztreonam > amoxicillin.

Conclusions:

  • β-Lactam antibiotics exhibit varied impacts on PAOs, with some enhancing EBPR processes.
  • Understanding antibiotic fate and toxicity is crucial for environmental risk assessment.
  • This study provides a theoretical basis for evaluating the biological toxicity of antibiotic pollutants in aquatic environments.