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Collimating micro-lens fiber array for noncontact near-infrared diffuse correlation tomography.

Shijie Feng1, Zhiguo Gui1, Xiaojuan Zhang1

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A novel noncontact optical probe for diffuse correlation tomography (DCT) enables faster, more robust imaging of tissue blood flow. This technology, termed FA-nc-DCT, improves upon existing methods for applications like breast cancer detection.

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Area of Science:

  • Biomedical Optics
  • Medical Imaging
  • Photonics

Background:

  • Near-infrared diffuse correlation spectroscopy/tomography (DCS/DCT) is a noninvasive technique for measuring tissue blood flow.
  • Current DCT systems face limitations in field of view and measurement time due to camera-based fiber arrays or scanning probes.
  • Accurate collection of light temporal autocorrelation curves (g2(τ)) is crucial for blood flow image reconstruction.

Purpose of the Study:

  • To design and validate a noncontact optical probe for DCT (FA-nc-DCT) to overcome limitations of existing systems.
  • To improve the speed, stability, and field of view for DCT blood flow imaging.
  • To enable robust imaging of blood flow in large human tissues and various disease states.

Main Methods:

  • Development of a noncontact optical probe using a collimating micro-lens fiber array integrated into a square base.
  • Implementation of an 8x8 optical switch to share laser and detector hardware, eliminating spatial scanning.
  • Validation using speed-varied phantom experiments and human cuff occlusion tests.

Main Results:

  • The FA-nc-DCT system precisely collected g2(τ) curves, yielding expected blood flow index (BFI) values in experiments.
  • Accurate reconstruction of flow anomalies in phantoms and ischemic muscle in human subjects was achieved.
  • The system demonstrated potential for fast and robust imaging, validated with a novel Nth-order linear imaging algorithm.

Conclusions:

  • The FA-nc-DCT system offers a significant advancement for noninvasive tissue blood flow imaging.
  • This technology overcomes previous limitations, enabling faster and more stable DCT measurements.
  • FA-nc-DCT shows great potential for clinical applications, including the imaging of human breast cancers and other diseases.