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Extravesical subtrigonal injection of 50 per cent ethanol for detrusor instability
R G Harris1, C E Constantinou, T A Stamey
1Department of Surgery, Stanford University Medical Center, California.
The Journal of Urology
|July 1, 1988
Summary
Ethanol injections for detrusor instability offer a promising treatment for refractory urinary incontinence. This minimally invasive procedure demonstrated significant success in improving bladder control in most patients.
Area of Science:
- Urology
- Minimally Invasive Surgery
- Pharmacological Therapy
Background:
- Urinary incontinence due to detrusor instability is often resistant to standard treatments.
- Conservative and pharmacological therapies may fail to resolve symptoms in many patients.
Observation:
- This study evaluated extravesical subtrigonal ethanol injections in 10 patients with refractory detrusor instability.
- The procedure involves injecting 50% ethanol into the subtrigonal region.
Findings:
- 90% of patients achieved detrusor stability post-injection.
- 60% of patients developed an acontractile bladder.
- 70% of patients remained dry or significantly improved at a mean 24-month follow-up.
- 90% experienced excellent results for at least 10 months, with one patient needing additional treatments.
Implications:
- Extravesical ethanol injection is a viable, effective treatment for refractory detrusor instability.
- The procedure offers a minimally invasive alternative with durable results.
- Potential complications include fistula formation, necessitating careful patient selection and management.
