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Controlled Manipulation and Active Sorting of Particles Inside Microfluidic Chips Using Bulk Acoustic Waves and

Kyriacos Yiannacou¹, Veikko Sariola¹

¹Faculty of Medicine and Health Technology, Tampere University, Korkeakoulunkatu 3, 33720 Tampere, Finland.

Langmuir : the ACS Journal of Surfaces and Colloids

|April 2, 2021

Summary

This study introduces a novel closed-loop system for precise 2D particle manipulation in microfluidic chips using ultrasound. Machine learning algorithms enable adaptive control, allowing for robust particle sorting and manipulation without prior system knowledge.

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Area of Science:

Microfluidics
Acoustic manipulation
Biotechnology

Background:

Ultrasound manipulation of microfluidic contents is crucial for applications like cell sorting and rare cell enrichment.
Existing methods using single ultrasonic transducers have limited control over single particle positioning.

Purpose of the Study:

To demonstrate closed-loop, two-dimensional (2D) particle manipulation within microfluidic chips using a single ultrasound transducer.
To develop a robust and adaptive control method that requires no prior knowledge of acoustic field characteristics.

Main Methods:

Utilizing machine vision to measure particle positions in real-time.
Employing multi-armed bandit algorithms to control ultrasound transducer frequency for particle manipulation.
Implementing a closed-loop system for adaptive, model-free control.

Main Results:

Achieved precise 2D manipulation of single particles and simultaneous manipulation of three particles.
Demonstrated robust particle control even in the presence of bubbles.
Successfully applied the method for active particle sorting into distinct outlets.

Conclusions:

The developed machine learning-based acoustic manipulation system offers precise, adaptive control without requiring system calibration or modeling.
This approach significantly enhances the capabilities of ultrasound-mediated microfluidic particle manipulation, enabling applications in unstructured environments.