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Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model
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Aortic aneurysm disease-Make room for chronobiology
Aleksandra Lopuszko1, Sven Zhen Cian Patrick Tan1, Wahaj Munir1
1Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Journal of Cardiac Surgery
|April 2, 2021
Summary
Aortic aneurysm (AA) incidence peaks in the morning and colder months, mirroring other cardiovascular events. Understanding these chronobiological patterns is key for developing new prevention strategies.
Area of Science:
- Chronobiology
- Cardiovascular Pathophysiology
- Atherosclerosis
Background:
- Aortic aneurysm (AA) is a significant cause of mortality, often resulting from atherosclerosis or genetic disorders.
- AAs are frequently asymptomatic until rupture, which has a high fatality rate.
- AA incidence may follow chronobiological patterns, similar to other cardiovascular diseases.
Purpose of the Study:
- To evaluate the association between circadian rhythms, seasonal variations, and genetic factors in AA pathogenesis.
- To review the impact of chronobiology on aortic aneurysm development and incidence.
Main Methods:
- Comprehensive literature review.
- Analysis of existing studies on chronobiology and aortic aneurysms.
Main Results:
- AA incidence peaks in the early morning (6-11 a.m.) and during colder months.
- AA incidence troughs in the evening and warmer months.
- These patterns resemble those observed in myocardial infarcts and cerebrovascular strokes.
Conclusions:
- A clear link exists between chronobiology and the incidence/pathogenesis of ruptured AA.
- The association is more pronounced in individuals with Marfan syndrome or vitamin D deficiency.
- Further research into chronotherapeutics is needed for precision medicine approaches to AA prevention.
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