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EPH/EPHRIN regulates cellular organization by actomyosin contractility effects on cell contacts

Abigail A Kindberg1,2,3,4,5, Vasudha Srivastava6, Jonathon M Muncie7,8,9,10

  • 1Program in Craniofacial Biology, University of California, San Francisco, San Francisco, CA.

The Journal of Cell Biology
|April 2, 2021
PubMed
Summary

EPH/EPHRIN signaling drives cell self-organization by increasing actomyosin contractility, which reduces cell-cell contact stability. This mechanism, independent of cell migration, governs tissue organization through interfacial tension.

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