Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Asymmetric Lipid Bilayer01:35

Asymmetric Lipid Bilayer

8.9K
Biological membranes show uneven distribution of different types of lipids in the inner and outer layers, resulting in transverse asymmetric membranes. The treatment of the erythrocyte membrane with the enzyme phospholipase confirmed the asymmetric nature of the lipid bilayer. The enzyme hydrolyzes lipids into fatty acids and hydrophilic groups. The phospholipase acts only on the outer layer of the membrane, while the inner layer remains intact. The phospholipase treatment resulted in 80%...
8.9K
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

1.1K
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
1.1K
Membrane Lipids01:32

Membrane Lipids

31.6K
Lipids are an essential component of all biological membranes. The average lipid content in mammalian membranes is 50%, though it can be as low as 20% in the inner mitochondrial membrane or as high as 80% in the myelin sheath present around the nerve cells.
Phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin are the most common phospholipids present in mammalian membranes. At physiological pH, phosphatidylserine is negatively charged, while the other three...
31.6K
Biosynthesis of Lipids01:29

Biosynthesis of Lipids

260
Microbial membranes exhibit remarkable diversity in lipid composition, reflecting evolutionary adaptations to various environmental conditions. The three domains of life—Bacteria, Archaea, and Eukarya—synthesize membrane lipids through distinct biosynthetic pathways, leading to fundamental structural differences that impact membrane stability, function, and adaptability.Fatty Acid-Based Lipids in Bacteria and EukaryaBacteria and eukaryotes share a common fatty acid biosynthesis...
260
Lipid-derived Compounds in the Human Body01:31

Lipid-derived Compounds in the Human Body

5.7K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
5.7K
Lipids as Anchors01:32

Lipids as Anchors

6.6K
In the plasma membrane, the lipids forming the bilayer can also act as an anchor to tether proteins to the membrane. The three main types of lipid anchors found in eukaryotes are – prenyl groups, fatty acyl groups, and glycosylphosphatidylinositol or GPI groups. Prenyl and fatty acyl groups act as anchors on the cytosolic surface of the membrane, whereas GPI anchors proteins on the extracellular side.
The carboxy-terminal of most of the prenylated proteins, such as Ras proteins, contains...
6.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cholesterol-dependent modulation of β-amyloid 1-40 peptide aggregation by membrane organization.

Journal of colloid and interface science·2026
Same author

Dengue Virus Capsid Protein Interaction With Nucleic Acids.

BioFactors (Oxford, England)·2026
Same author

Dynamics of an RNase H-Responsive Tetrahedral DNA Nanostructure for Efficient Intracellular microRNA Inhibition.

Bioconjugate chemistry·2026
Same author

Drug-Coated Balloon Only Percutaneous Coronary Intervention for De-Novo Chronic Total Occlusion: Insights From the Multicenter International CTO-DENOVO Registry.

The American journal of cardiology·2026
Same author

Crofton Risk and Relative Transactional Entropy.

Entropy (Basel, Switzerland)·2026
Same author

Gas-depleted planet formation occurred in the four-planet system around the red dwarf LHS 1903.

Science (New York, N.Y.)·2026

Related Experiment Video

Updated: Nov 10, 2025

Cell-Free Production of Proteoliposomes for Functional Analysis and Antibody Development Targeting Membrane Proteins
08:46

Cell-Free Production of Proteoliposomes for Functional Analysis and Antibody Development Targeting Membrane Proteins

Published on: September 22, 2020

4.1K

Lipid membrane-based therapeutics and diagnostics.

Patrícia M Carvalho1, Marcin Makowski1, Marco M Domingues1

  • 1Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028, Lisbon, Portugal.

Archives of Biochemistry and Biophysics
|April 2, 2021
PubMed
Summary
This summary is machine-generated.

Lipid membranes offer promising solutions for drug delivery and diagnostics, enhancing therapeutic efficacy and enabling early disease detection. These biocompatible platforms, including liposomes, show potential to overcome drug development challenges.

Keywords:
Drug delivery systemsErythrocytesExtracellular vesiclesLiposomesMembrane-based diagnosticsMembranesTranslational research

More Related Videos

Lipidomics and Transcriptomics in Neurological Diseases
09:58

Lipidomics and Transcriptomics in Neurological Diseases

Published on: March 18, 2022

3.7K
Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications
08:19

Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications

Published on: November 17, 2015

18.2K

Related Experiment Videos

Last Updated: Nov 10, 2025

Cell-Free Production of Proteoliposomes for Functional Analysis and Antibody Development Targeting Membrane Proteins
08:46

Cell-Free Production of Proteoliposomes for Functional Analysis and Antibody Development Targeting Membrane Proteins

Published on: September 22, 2020

4.1K
Lipidomics and Transcriptomics in Neurological Diseases
09:58

Lipidomics and Transcriptomics in Neurological Diseases

Published on: March 18, 2022

3.7K
Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications
08:19

Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications

Published on: November 17, 2015

18.2K

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Drug discovery faces low success rates due to safety and efficacy issues.
  • Early disease diagnosis improves patient outcomes and reduces healthcare costs.
  • Lipid membranes present unique biocompatibility and physicochemical properties for therapeutic applications.

Purpose of the Study:

  • To review lipid membrane-based strategies for drug delivery and diagnostics.
  • To evaluate the advantages and limitations of these advanced therapeutic platforms.
  • To highlight the potential of lipid membranes in overcoming drug development barriers.

Main Methods:

  • Examination of synthetic lipid membrane-based drug delivery systems, focusing on liposomes.
  • Discussion of biological lipid membrane structures as drug carriers in clinical evaluation.
  • Review of lipid membrane applications in diagnostic biosensors.

Main Results:

  • Liposomes represent a clinically validated synthetic lipid-based drug delivery system.
  • Biomimetic lipid membrane strategies show potential for extended in vivo drug circulation.
  • Lipid membrane-based diagnostics are under active development for early disease detection.

Conclusions:

  • Lipid membranes are versatile platforms for both enhancing drug delivery and enabling diagnostics.
  • These strategies offer a promising approach to improve drug development success rates and patient care.
  • Further research into lipid membrane applications could revolutionize therapeutic and diagnostic fields.