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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

3.3K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Epigenetic Regulation01:46

Epigenetic Regulation

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Cancer02:18

Cancer

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
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Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
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Related Experiment Video

Updated: Nov 10, 2025

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
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Cancer epigenetics: Past, present and future.

Jae Eun Lee1, Mi-Young Kim2

  • 1Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.

Seminars in Cancer Biology
|April 2, 2021
PubMed
Summary

Epigenetic changes, not just genetic mutations, drive cancer. Research into these epigenetic factors is leading to new cancer treatments and diagnostic markers.

Keywords:
Cancer epigeneticsChromatin modificationEpigenetic anti-cancer drugsEpigenetic deregulation

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Area of Science:

  • Oncology
  • Molecular Biology
  • Epigenetics

Background:

  • Historically, cancer was attributed solely to genetic mutations.
  • Epigenetic alterations are now recognized as key drivers of carcinogenesis and cancer progression.
  • Deregulation of chromatin modifiers and non-coding RNAs significantly impacts gene expression in cancer cells.

Purpose of the Study:

  • To review the established findings in cancer epigenetics.
  • To discuss current research trends and emerging epigenetic regulators.
  • To explore future directions for novel cancer therapeutics and prognostic markers.

Main Methods:

  • Review of existing literature on cancer epigenetics.
  • Analysis of epigenetic mechanisms in carcinogenesis.
  • Discussion of chromatin modifiers, non-coding RNAs, and their roles.

Main Results:

  • Epigenetic deregulation, including aberrant chromatin modification, is a primary driver of cancer.
  • Targeting epigenetic factors has led to novel anticancer therapeutic strategies.
  • Ongoing research focuses on new epigenetic regulators, tumor microenvironment, and heterogeneity.

Conclusions:

  • Epigenetics plays a crucial role in cancer development and progression.
  • Understanding epigenetic mechanisms is vital for developing effective cancer therapies.
  • Future research holds promise for identifying new prognostic markers and treatments.