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Evaluation of the Storage Stability of Extracellular Vesicles
Published on: May 22, 2019
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Factors Affecting Extracellular Vesicles Based Drug Delivery Systems.
Isha Gaurav1, Abhimanyu Thakur2, Ashok Iyaswamy1,3
1School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.
Molecules (Basel, Switzerland)
|April 3, 2021
Summary
Extracellular vesicles (EVs) are promising for targeted drug delivery systems (DDS). Surface modification and optimized isolation enhance their therapeutic potential compared to traditional nanodrug delivery systems (NDDS).
Area of Science:
- Biotechnology
- Nanomedicine
- Cell Biology
Background:
- Extracellular vesicles (EVs) are crucial for intercellular communication in physiological and pathological states.
- Surface modification of EVs with ligands enables targeted delivery of therapeutic payloads.
- EV-based drug delivery systems (DDS) offer potential advantages over conventional nanodrug delivery systems (NDDS).
Purpose of the Study:
- To review recent advancements in EV-based DDS.
- To compare EVs (liposomes, exosomes) with conventional NDDS.
- To discuss challenges and future directions for EV-based DDS.
Main Methods:
- Literature review of studies on EV-based DDS.
- Comparison of liposomes and exosomes for DDS applications.
- Analysis of EV isolation, characterization, surface modification, and cargo encapsulation techniques.
Main Results:
- EVs offer unique benefits for DDS due to their biological origin and surface properties.
- Optimized isolation, yield, and characterization are critical for effective EV-based DDS.
- Various methods exist for EV surface modification and therapeutic cargo encapsulation.
Conclusions:
- EV-based DDS represent a rapidly evolving field with significant therapeutic potential.
- Further research is needed to overcome challenges in EV production and application for enhanced DDS.
- Surface-modified EVs hold promise for next-generation targeted therapies.
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