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Related Experiment Video

Updated: Nov 10, 2025

Author Spotlight: The Significance of Isolation, Culture, and Adipogenic Induction of SVF-Derived Preadipocytes from Mouse Perivascular Adipose Tissue
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Perirenal Adipose Tissue-Current Knowledge and Future Opportunities.

Adriana Grigoraș1, Raluca Anca Balan1, Irina-Draga Căruntu1

  • 1Department of Morphofunctional Sciences I, "Grigore T. Popa" University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania.

Journal of Clinical Medicine
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PubMed
Summary

Perirenal adipose tissue (PRAT) is vital for cardiovascular and kidney health. This review explores PRAT's role in diseases like hypertension, obesity, and cancer, highlighting its potential as an endocrine organ.

Keywords:
cardiovascular diseaseschronic kidney diseaseobesityperirenal adipose tissue

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Area of Science:

  • Endocrinology
  • Cardiovascular Science
  • Nephrology
  • Oncology

Background:

  • Perirenal adipose tissue (PRAT), a visceral fat component, influences cardiovascular and kidney homeostasis.
  • PRAT comprises diverse cells including white and brown adipocytes, immune cells, and nerve endings, forming a complex microenvironment.

Purpose of the Study:

  • To review current knowledge on PRAT's composition and function.
  • To discuss PRAT's contribution to the pathogenesis of hypertension, obesity, chronic kidney diseases, and cancer progression.
  • To explore emerging research on PRAT as an endocrine organ and brown adipocyte activation.

Main Methods:

  • Literature review synthesizing existing research on PRAT.
  • Analysis of PRAT's role in various disease models.
  • Discussion of novel therapeutic targets related to PRAT.

Main Results:

  • PRAT significantly contributes to hypertension, obesity, and chronic renal diseases.
  • PRAT plays a role in tumor progression, suggesting potential therapeutic avenues.
  • Activation of dormant brown adipocytes in PRAT is a key area for obesity research.

Conclusions:

  • PRAT is a critical factor in maintaining physiological homeostasis and disease pathogenesis.
  • Understanding PRAT's endocrine functions and cellular dynamics offers new insights into metabolic and cardiovascular diseases.
  • Targeting PRAT may provide novel strategies for treating obesity, kidney disease, and cancer.