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Related Experiment Video

Updated: Nov 10, 2025

Visible-light Induced Reduction of Graphene Oxide Using Plasmonic Nanoparticle
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A New Approach to Obtaining Nano-Sized Graphene Oxide for Biomedical Applications.

Paulina Bolibok1, Bartosz Szymczak2, Katarzyna Roszek2

  • 1Physicochemistry of Carbon Materials Research Group, Faculty of Chemistry, Nicolaus Copernicus University in Toruń, Gagarina 7, 87-100 Toruń, Poland.

Materials (Basel, Switzerland)
|April 3, 2021
PubMed
Summary

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A novel method creates size-controlled nanographene oxide (n-GO) with preserved functionalities. This biocompatible n-GO shows reduced toxicity, making it ideal for drug and biomolecule delivery systems.

Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Graphene oxide (GO) is a widely utilized material with significant potential.
  • Controlling the size and properties of GO is crucial for advanced applications.
  • Existing methods for GO modification may alter its essential functionalities.

Purpose of the Study:

  • To develop a new method for producing size-tunable nanographene oxide (n-GO).
  • To characterize the structural and chemical properties of the synthesized n-GO.
  • To evaluate the biocompatibility and potential applications of n-GO, particularly in drug delivery.

Main Methods:

  • Controlled ultrasonication of graphene oxide (GO) in dimethyl sulfoxide (DMSO).
  • Varied sonication times to regulate sheet size through cutting and re-aggregation.
Keywords:
aggregationcapillary vesselscytotoxicitydimethyl sulfoxide (DMSO)nanographene oxideultrasonication

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  • Spectral analysis (e.g., Raman, FTIR) to confirm structural integrity and surface chemistry.
  • Biocompatibility assessment using cell viability assays and EC50 determination.

    • Main Results:

    • Successfully produced n-GO sheets down to 200 nm with high homogeneity.
    • Minor spectral changes observed, indicating preserved oxygen functionalities and no reduction.
    • Significant increase in half-maximal effective concentration (EC50) from 50 to 250 µg/mL, demonstrating enhanced biocompatibility.
    • n-GO showed no adverse effects on blood flow or cellular toxicity.

    Conclusions:

    • The novel ultrasonication method yields size-controlled n-GO with intact oxygen functionalities.
    • The resulting n-GO exhibits excellent biocompatibility and low toxicity.
    • n-GO is a promising candidate for systemic drug and biomolecule delivery applications.