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Updated: Nov 10, 2025
10:39
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
18.5K
Oxygen Therapy in Headache Disorders: A Systematic Review
Tiziana Ciarambino1, Gennaro Sansone2, Giovanni Menna2
1Internal Emergency Department, Hospital of Marcianise, 80125 ASL Caserta, Italy.
Brain Sciences
|April 3, 2021
Summary
High flow oxygen therapy did not significantly improve headache disorders compared to placebo. This review of six studies found no difference in headache resolution, suggesting oxygen is not an effective treatment for migraines.
Area of Science:
- Neurology
- Pain Management
- Respiratory Medicine
Background:
- Migraine affects approximately 14.7% of the global population.
- Non-steroidal anti-inflammatory drugs (NSAIDs) are common migraine treatments but have side effects.
- Oxygen therapy presents a potential alternative for headache management.
Purpose of the Study:
- To systematically review and analyze the efficacy of high flow oxygen for headache disorders.
- To compare high flow oxygen therapy against placebo treatments for headache management.
Main Methods:
- Literature search conducted on PubMed, Web of Science, and Scopus (1980-October 2020).
- Search terms included 'oxygen therapy', 'headache', and 'migraine'.
- Six studies using high flow oxygen for headache disorders were included and qualitatively analyzed.
Main Results:
- A meta-analysis of six studies was performed.
- No significant pooled resolution of headache disorders was observed in the oxygen therapy group compared to placebo (OR 2.08, 95% CI 0.92-4.70).
- The result indicated no statistically significant difference between the treatment groups.
Conclusions:
- The systematic review found no significant differences between high flow oxygen and placebo treatments.
- High flow oxygen therapy is not demonstrably more effective than placebo for managing headache disorders.
- Further research may be needed to explore other oxygen delivery methods or patient populations.
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