Related Experiment Video

Updated: Nov 10, 2025

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method
09:06

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method

Published on: October 7, 2025

120

A Systematic Review of MicroRNAs Involved in Cervical Cancer Progression

Rhafaela Lima Causin1, Ana Julia Aguiar de Freitas1, Cassio Murilo Trovo Hidalgo Filho2

  • 1Molecular Oncology Research Center, Barretos Cancer Hospital, Teaching and Research Institute, Barretos-SP 14784-400, Brazil.

Cells
|April 3, 2021
PubMed

Insights

This systematic review identifies 26 differentially expressed microRNAs (DEmiRNAs) crucial for cervical cancer (CC) progression. These microRNAs are linked to key cancer hallmarks and may serve as biomarkers for CC classification and monitoring.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression.
  • Dysregulation of miRNA expression is implicated in various cancers, including cervical cancer (CC).
  • Understanding miRNA roles in CC progression is vital for developing diagnostic and therapeutic strategies.

Purpose of the Study:

  • To systematically review and analyze studies on miRNA expression in cervical cancer progression.
  • To identify common outcomes and target gene interactions of miRNAs in CC.
  • To explore the potential of miRNAs as biomarkers for CC classification and monitoring.

Main Methods:

  • Systematic literature search of PubMed MEDLINE, EMBASE, and Google Scholar (April 2010-April 2020).
  • Inclusion of 27 published reports involving 1721 CC cases and 1361 noncancerous controls.
  • Analysis based on PICO (participants, interventions, comparisons, outcomes) criteria.

Main Results:

  • Identified 26 differentially expressed microRNAs (DEmiRNAs) across different International Federation of Gynecology and Obstetrics (FIGO) stages of CC.
  • Found associations between specific dysregulated miRNAs and distinct stages of CC development.
  • DEmiRNAs were functionally involved in core cancer hallmarks: evading growth suppressors, replicative immortality, invasion/metastasis, resisting cell death, and sustained proliferation.

Conclusions:

  • Dysregulated miRNAs play a significant role in the development and progression of cervical cancer.
  • Stage-specific miRNAs show potential as biomarkers for CC classification and monitoring.
  • Further research into miRNA regulatory pathways could lead to novel therapeutic targets for CC.
Keywords:
cervical cancercervical cancer progressionmicroRNA

More Related Videos

miRNA Expression Analyses in Prostate Cancer Clinical Tissues11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

11.0K
An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells09:45

An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells

Published on: May 21, 2019

8.6K

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.4K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
22.9K