Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

MicroRNAs01:22

MicroRNAs

3.4K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.4K
MicroRNAs01:22

MicroRNAs

22.9K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
22.9K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

4.0K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.0K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

7.3K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
7.3K
Metastasis02:30

Metastasis

6.0K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
6.0K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

6.1K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
6.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

AP1 Transcription Factor in the Regulation of the Urokinase Plasminogen Activation System.

Biomolecules·2026
Same author

Downregulation of Gene Expression by Alpha Satellite Transcripts.

International journal of molecular sciences·2025
Same author

The Cellular and Molecular Characteristics of Postnatal Human Thymus Stromal Stem Cells.

Biomedicines·2025
Same author

Urokinase Plasminogen Activation System Modulation in Transformed Cell Lines.

International journal of molecular sciences·2025
Same author

Molecular Diagnostics in the Postgenomic Era.

Bioengineering (Basel, Switzerland)·2025
Same author

RNA-Sequencing Identification of Genes Supporting HepG2 as a Model Cell Line for Hepatocellular Carcinoma or Hepatocytes.

Genes·2024

Related Experiment Video

Updated: Nov 10, 2025

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

7.8K

MiR-7 in Cancer Development.

Petra Korać1, Mariastefania Antica2, Maja Matulić1

  • 1Department of Biology, Division of Molecular Biology, Faculty of Science, University of Zagreb, Horvatovac 102, 10000 Zagreb, Croatia.

Biomedicines
|April 3, 2021
PubMed
Summary

MicroRNAs (miRNAs), like miR-7, regulate cell processes and can suppress tumors. This study explores miR-7

Keywords:
cancer cellgene expressionmiR-7microRNAstumor suppressor

More Related Videos

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

11.0K
Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases
09:48

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases

Published on: August 23, 2024

593

Related Experiment Videos

Last Updated: Nov 10, 2025

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

7.8K
miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

11.0K
Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases
09:48

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases

Published on: August 23, 2024

593

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • MicroRNAs (miRNAs) are key regulators of gene expression, influencing cellular signaling pathways.
  • Some miRNAs, termed oncomirs, promote cancer, while others act as tumor suppressors.
  • miR-7 is an ancient miRNA primarily functioning as a tumor suppressor, impacting pathways like PI3K and MAPK.

Purpose of the Study:

  • To elucidate the multifaceted roles of miR-7 in cellular processes and its implications in various cancers.
  • To investigate miR-7's function as a tumor suppressor by downregulating proliferation, survival, and migration, while promoting apoptosis.
  • To explore miR-7's potential as a biotherapeutic agent.

Main Methods:

  • Review of existing literature on miRNA function and cancer biology.
  • Analysis of miR-7's involvement in PI3K and MAPK signaling pathways.
  • Examination of miR-7 deregulation in various tumor types, including brain, liver, lung, and pancreas.

Main Results:

  • miR-7 suppresses tumor development by inhibiting cell proliferation and survival, and stimulating apoptosis.
  • Downregulation of miR-7 is linked to glioblastoma cell proliferation and is observed in other cancers.
  • miR-7 can act as an oncomir in specific lung and oral carcinomas.

Conclusions:

  • miR-7 is a critical tumor suppressor miRNA with diverse roles in cell signaling, differentiation, and homeostasis.
  • Dysregulation of miR-7 contributes to tumorigenesis across multiple cancer types.
  • Further research into miR-7's functions may unlock its potential for cancer biotherapeutics.