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Comparative evaluation of two direct compression lactose grades for pyridoxine hydrochloride tablets
1Department of Pharmaceutical Technology and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka.
Die Pharmazie
|March 1, 1988
Abstract:
Fast flow lactose (FFL) and anhydrous lactose (AHL) were comparatively investigated for the manufacture of pyridoxine hydrochloride tablets. The results showed that drug/FFL formulations possessed better performance. Harder tablets were, however, compressed from AHL blends. Linear relationships which correlate tablet physical properties to excipient concentration in a given formulation were established. Tablet batches formulated with FFL dissolved in shorter times und showed better stability characteristics on aging.