Related Experiment Video
Updated: Nov 10, 2025
An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
Anti-Inflammatory and Immune Modulatory Effects of Synbio-Glucan in an Atopic Dermatitis Mouse Model
Yoon-Hwan Kim1, Min Soo Kang2, Tae Hyeong Kim2
1Department of Veterinary Internal Medicine and Institute of Veterinary Science, College of Veterinary Medicine, Kangwon National University, Chuncheon-si 24341, Korea.
Abstract:
Many trials have been conducted to treat atopic dermatitis (AD), but these therapies are generally unsuccessful because of their insufficiency or side effects. This study examined the efficacy of β-glucan derived from oats with fermented probiotics (called Synbio-glucan) on an AD-induced mouse model. For the experiment, Nc/Nga mice were exposed to a house dust mite extract (HDM) to induce AD. The mice were placed in one of four groups: positive control group, Synbio-glucan topical treatment group, Synbio-glucan dietary treatment group, and Synbio-glucan topical + dietary treatment group. The experiment revealed no significant difference in the serum IgE concentration among the groups. Serum cytokine antibody arrays showed that genes related to the immune response were enriched. A significant difference in the skin lesion scores was observed between the groups. Compared to the control group tissue, skin lesions were alleviated in the Synbio-glucan topical treatment group and Synbio-glucan dietary treatment group. Interestingly, almost normal structures were observed within the skin lesions in the Synbio-glucan topical + dietary treatment group. Overall, the β-glucan extracted from oats and fermented probiotic mixture is effective in treating atopic dermatitis.
Insights
Synbio-glucan, a mixture of oat-derived beta-glucan and fermented probiotics, effectively treats atopic dermatitis (AD) in mice. Both topical and dietary applications improved skin lesions, with combined use showing near-normal skin structure.
Area of Science:
- Immunology
- Dermatology
- Microbiology
Background:
- Atopic dermatitis (AD) treatments often fail due to insufficiency or side effects.
- Novel therapeutic strategies are needed for effective AD management.
- Beta-glucan and probiotics show potential in modulating immune responses.
Purpose of the Study:
- To evaluate the efficacy of Synbio-glucan (oat-derived beta-glucan with fermented probiotics) in an AD mouse model.
- To compare the effects of topical, dietary, and combined Synbio-glucan treatments on AD.
- To investigate the impact of Synbio-glucan on immune markers and skin pathology in AD.
Main Methods:
- An atopic dermatitis mouse model was established using house dust mite extract (HDM) in Nc/Nga mice.
- Mice were divided into four groups: positive control, topical Synbio-glucan, dietary Synbio-glucan, and combined topical + dietary Synbio-glucan.
- Serum IgE levels, cytokine profiles, and skin lesion scores were analyzed.
Main Results:
- No significant differences in serum IgE concentration were observed across groups.
- Serum cytokine antibody arrays indicated enrichment of immune response-related genes.
- Significant alleviation of skin lesion scores was noted in topical and dietary Synbio-glucan groups.
- The combined topical and dietary treatment group exhibited near-normal skin structures.
Conclusions:
- Synbio-glucan demonstrates significant efficacy in ameliorating atopic dermatitis symptoms in a mouse model.
- Both topical and dietary administration routes are effective, with combined use yielding the best results.
- This oat-derived beta-glucan and fermented probiotic mixture represents a promising therapeutic approach for atopic dermatitis.
