Related Experiment Video

Updated: Nov 10, 2025

Analysis of Physiologic E-Selectin-Mediated Leukocyte Rolling on Microvascular Endothelium
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Published on: February 11, 2009

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E-selectin negatively regulates polymorphonuclear neutrophil transmigration through altered endothelial junction

Dandan Huang1,2, Qihan Ding1,2, Shenbao Chen1,2

  • 1Center for Biomechanics and Bioengineering, Key Laboratory of Microgravity (National Microgravity Laboratory) and Beijing Key Laboratory of Engineered Construction and Mechanobiology, Institute of Mechanics, Chinese Academy of Sciences, Beijing, China.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|April 3, 2021
PubMed
Summary

E-selectins negatively regulate neutrophil transmigration by impacting endothelial cell plasticity and junctional integrity. This finding clarifies mechanisms of leukocyte TEM and informs inflammatory response research.

Keywords:
E-selectincytoskeletal remodelingendothelial integrityneutrophiltransmigration

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