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Updated: Nov 10, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
TransforMED: End-to-Εnd Transformers for Evidence-Based Medicine and Argument Mining in medical literature
Nikolaos Stylianou1, Ioannis Vlahavas1
1School of Informatics, Aristotle University of Thessaloniki, Greece.
Abstract:
Argument Mining (AM) refers to the task of automatically identifying arguments in a text and finding their relations. In medical literature this is done by identifying Claims and Premises and classifying their relations as either Support or Attack. Evidence-Based Medicine (EBM) refers to the task of identifying all related evidence in medical literature to allow medical practitioners to make informed choices and form accurate treatment plans. This is achieved through the automatic identification of Population, Intervention, Comparator and Outcome entities (PICO) in the literature to limit the collection to only the most relevant documents. In this work, we combine EBM with AM in medical literature to increase the performance of the individual models and create high quality argument graphs, annotated with PICO entities. To that end, we introduce a state-of-the-art EBM model, used to predict the PICO entities and two novel Argument Identification and Argument Relation classification models that utilize the PICO entities to enhance their performance. Our final system works in a pipeline and is able to identify all PICO entities in a medical publication, the arguments presented in them and their relations.
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