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Pituitary thyrotoxicosis presenting as abnormal thyroid function testing during pregnancy: a case report.

David George Jackson1, John Parker2, Thomas Cummings3

  • 1Wilmington Health Endocrinology, 2421 Silver Stream Lane, Wilmington, NC, 28401, USA.

Journal of Medical Case Reports
|April 4, 2021
PubMed
Summary
This summary is machine-generated.

Central hyperthyroidism, a rare condition caused by pituitary adenomas, can present subtly. Surgical removal of the adenoma effectively resolved symptoms in a pregnant patient, restoring a euthyroid state.

Keywords:
MacroadenomaPituitaryPregnancyThyrotoxicosis

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Area of Science:

  • Endocrinology
  • Pituitary Disorders
  • Thyroid Disorders

Background:

  • Central hyperthyroidism stems from thyrotrope pituitary adenomas.
  • It involves elevated thyroid-stimulating hormone (TSH), thyroxine (T4), and triiodothyronine (T3).
  • Goiter is a common clinical manifestation.

Observation:

  • A 30-year-old pregnant woman presented with abnormal thyroid function and multinodular goiter.
  • Postpartum, persistent elevated TSH, T4, and T3 were noted.
  • Magnetic resonance imaging revealed a large pituitary macroadenoma.

Findings:

  • Surgical resection of the pituitary macroadenoma was performed.
  • The patient achieved a sustained euthyroid state post-surgery.
  • This case highlights successful management of central hyperthyroidism via surgical intervention.

Implications:

  • Central hyperthyroidism can manifest without overt thyrotoxicosis symptoms.
  • Surgical treatment of pituitary adenomas offers a viable therapeutic option.
  • Effective management restores hormonal balance and resolves hyperthyroid conditions.