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Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
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Updated: Nov 10, 2025

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment
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Breast cancer.

Sibylle Loibl1, Philip Poortmans2, Monica Morrow3

  • 1German Breast Group, Neu-Isenburg, Germany; Centre for Haematology and Oncology Bethanien, Frankfurt, Germany.

Lancet (London, England)
|April 4, 2021
PubMed
Summary
This summary is machine-generated.

Breast cancer treatment has evolved with molecular and immunomarkers, enabling personalized neoadjuvant therapies and de-escalated radiotherapy. Advanced targeted agents and immunotherapies now offer tailored options for metastatic disease.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • Breast cancer remains a leading global cancer, with understanding evolving through molecular characterization.
  • Key markers include immunohistochemical (ER, PR, HER2, Ki-67), genomic (BRCA1/2, PIK3CA), and immunomarkers (TILs, PD-L1).

Purpose of the Study:

  • To highlight the advancements in breast cancer diagnostics and therapeutics.
  • To underscore the shift towards personalized medicine based on molecular profiling.

Main Methods:

  • Review of current diagnostic algorithms incorporating multiple biomarker combinations.
  • Analysis of neoadjuvant and metastatic treatment strategies, including targeted agents and immunotherapy.

Main Results:

  • Neoadjuvant combination therapies (HER2-positive, triple-negative) are standard, guiding surgical de-escalation and post-treatment strategies.
  • Endocrine therapy (5-10 years) and chemotherapy are used for ER-positive tumors based on risk.
  • Metastatic treatment includes CDK4/6, PI3K, PARP inhibitors, and anti-PD-L1 immunotherapy, tailored to tumor profile.

Conclusions:

  • Breast cancer therapy is increasingly complex, driven by biomarker advancements.
  • Personalized treatment strategies are becoming standard, from neoadjuvant care to managing metastatic disease.