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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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Accessory Structures of the Skin: Sebaceous Glands01:21

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A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
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EPS and iPS Cells in Disease Research01:21

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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Papillary Dermis01:11

Papillary Dermis

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

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Psoriasis.

Christopher E M Griffiths1, April W Armstrong2, Johann E Gudjonsson3

  • 1Dermatology Centre, Salford Royal NHS Foundation Trust, University of Manchester, Manchester, UK; NIHR Manchester Biomedical Research Centre, Manchester, UK.

Lancet (London, England)
|April 4, 2021
PubMed
Summary
This summary is machine-generated.

Psoriasis is a chronic skin disease linked to genetics and environment. While incurable, early intervention and lifestyle changes can significantly reduce its impact.

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Area of Science:

  • Dermatology
  • Immunology
  • Genetics

Background:

  • Psoriasis is a prevalent, chronic skin condition with global impact.
  • Associated comorbidities include depression, psoriatic arthritis, and cardiometabolic syndrome.
  • Chronic plaque psoriasis (psoriasis vulgaris) involves genetic predisposition (HLA-C*06:02) and environmental factors.

Purpose of the Study:

  • To review the pathogenesis of psoriasis.
  • To discuss current and emerging therapeutic strategies.
  • To emphasize comprehensive patient management.

Main Methods:

  • Review of immunological and genetic studies.
  • Analysis of therapeutic outcomes for biological agents.
  • Examination of disease management strategies.

Main Results:

  • Interleukin-17 (IL-17) and Interleukin-23 (IL-23) are identified as key drivers of psoriasis.
  • Biological therapies targeting IL-17, IL-23, and Tumor Necrosis Factor-alpha (TNFα) have transformed severe psoriasis care.
  • Psoriasis management requires a personalized approach, addressing physical, psychological, and associated health issues.

Conclusions:

  • Psoriasis is a complex disease with significant individual and societal burden.
  • Current treatments, particularly biologics, offer effective management for severe cases.
  • Holistic management focusing on early treatment, comorbidity prevention, and lifestyle modification is crucial for improving patient outcomes.