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A Novel Tenorrhaphy Suture Technique with Tissue Engineered Collagen Graft to Repair Large Tendon Defects
Published on: December 10, 2021
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Double layer composite membrane for preventing tendon adhesion and promoting tendon healing
Zuofa Yan1, Xiangjun Meng2, Yun Su1
1Department of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, Liaoning, PR China.
Summary
This study developed a double-layer membrane combining an anti-inflammatory drug and growth factor to prevent tendon adhesion and promote healing. The novel system effectively reduced inflammation and enhanced collagen production for better tendon repair.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Drug Delivery Systems
Background:
- Tendon adhesion is a common complication after surgery, hindering functional recovery.
- Existing treatments like electrospun membranes and hydrogels have limitations in preventing adhesion and promoting healing.
- Basic fibroblast growth factor (bFGF) promotes tendon healing but requires a protective carrier due to its instability.
Purpose of the Study:
- To develop a novel double-layer composite membrane for preventing tendon adhesion and promoting Achilles tendon healing.
- To create a drug delivery system that combines anti-inflammatory and growth factor functionalities.
- To evaluate the efficacy of the composite membrane in reducing inflammation and enhancing tendon repair.
Main Methods:
- Fabrication of a poly(lactic-co-glycolic) acid (PLGA) electrospun membrane loaded with ibuprofen (EMI).
- Synthesis of Methoxy poly(ethylene glycol)-block-poly(L-valine) (PEG-PLV) hydrogel and incorporation of bFGF (PLVB).
- Assembly of a double-layer composite membrane (EMI-PLVB) by applying PLVB onto EMI and in vitro/in vivo evaluation.
Main Results:
- Continuous in vitro release of ibuprofen (IBU) and bFGF from the EMI-PLVB membrane.
- Significant reduction in inflammatory factors at the tendon healing site in vivo.
- Increased production of type I and type III collagen at the tendon healing site, indicating enhanced healing.
Conclusions:
- The developed double-layer composite membrane effectively prevents tendon adhesion.
- The system promotes tendon healing by reducing inflammation and stimulating collagen synthesis.
- This drug release system holds promise for improving outcomes in tendon injury treatment.
