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Published on: September 18, 2020
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Gut microbes in gastrointestinal cancers
Fei Wang1, Meiyi Song2, Xiya Lu2
1Division of Gastroenterology, Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China.
Seminars in Cancer Biology
|April 4, 2021
Summary
Gut microbes (GMs) are linked to gastrointestinal cancers. Research explores their role, mechanisms, and potential treatments like fecal microbiota transplantation (FMT) for prevention and diagnosis.
Area of Science:
- Microbiology
- Oncology
- Gastroenterology
Background:
- Gut microbes (GMs), primarily bacteria, are crucial for physiological processes and health.
- Gastrointestinal cancers are significant global health concerns.
- Emerging evidence links complex GM compositions to gastrointestinal cancer development.
Purpose of the Study:
- To review the latest research on the role of gut microbes in gastrointestinal cancers.
- To explore the correlation between GMs and gastrointestinal cancers.
- To examine the influence mechanisms and therapeutic applications of GMs in this context.
Main Methods:
- Review of recent scientific literature.
- Analysis of studies utilizing metagenomic technology and next-generation sequencing.
- Synthesis of findings on GM-disease associations and interventions.
Main Results:
- Gut microbes are significantly associated with the occurrence and progression of gastrointestinal cancers.
- Fecal microbiota transplantation (FMT) and probiotics show potential in treating and preventing these cancers.
- Understanding GM influence mechanisms offers new diagnostic and therapeutic avenues.
Conclusions:
- Gut microbes play a critical role in gastrointestinal cancer development.
- Interventions targeting GMs, such as FMT, hold promise for cancer prevention and treatment.
- Further research into GM-cancer interactions can guide future strategies for early diagnosis and management.
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