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PBK Expression Is Associated With Prognosis of Patients With Oral Squamous Cell Carcinoma Treated With Radiotherapy:
Wan-Nien Yu1, Heng-Fu Lin1, Y I Lee2
1Department of Otorhinolaryngology, Head and Neck Surgery, Changhua Christian Hospital, Changhua, Taiwan, R.O.C.
Anticancer Research
|April 4, 2021
Summary
PDZ-binding kinase (PBK) shows promise as a prognostic marker in oral squamous cell carcinoma (OSCC) treated with radiotherapy. High PBK expression is linked to better survival rates, particularly in advanced stages.
Area of Science:
- Oncology
- Cancer Biology
- Radiotherapy Research
Background:
- Oral squamous cell carcinoma (OSCC) is a significant global health concern.
- Radiotherapy is a primary treatment modality for OSCC.
- Identifying reliable prognostic markers is crucial for optimizing patient management.
Purpose of the Study:
- To evaluate the prognostic significance of PDZ-binding kinase (PBK) expression in patients with OSCC undergoing radiotherapy.
- To determine if PBK expression levels correlate with clinical outcomes in OSCC.
Main Methods:
- Immunohistochemistry was employed to assess PBK immunoreactivity in tumor specimens from 179 primary OSCC patients.
- Statistical analysis was performed to correlate PBK expression with clinicopathological features and survival rates.
Main Results:
- High PBK expression was associated with advanced N-stage in OSCC.
- Patients with high total PBK expression exhibited a greater 5-year survival rate compared to those with low expression.
- PBK expression remained a significant independent predictor of favorable outcomes, especially in advanced stage III/IV disease.
Conclusions:
- PBK expression serves as an independent prognostic marker for OSCC patients treated with radiotherapy.
- PBK is particularly valuable for predicting outcomes in patients with advanced-stage OSCC.
- This finding supports the potential clinical utility of PBK as a biomarker in OSCC management.
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