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Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
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Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

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Compromised Renal and Hepatic Functions and Unsteady Cellular Redox State during Preeclampsia and Gestational

Jigeesha Mishra1, Shailendra Kumar Srivastava1, Kanti Bhooshan Pandey2

  • 1Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj, India.

Archives of Medical Research
|April 5, 2021
PubMed

Insights

Preeclampsia (PE) significantly impacts renal and hepatic functions, while gestational diabetes mellitus (GDM) also shows liver and kidney dysfunction. Both conditions exhibit impaired redox states, suggesting a role for antioxidant therapy.

Area of Science:

  • Obstetrics and Gynecology
  • Biochemistry
  • Pathophysiology

Background:

  • Preeclampsia (PE) and gestational diabetes mellitus (GDM) are significant pregnancy complications.
  • Assessing renal, hepatic, and redox status is crucial for understanding these conditions.

Purpose of the Study:

  • To evaluate renal and hepatic functions in pregnancies with PE and GDM.
  • To investigate the redox state in PE and GDM pregnancies.

Main Methods:

  • Serum biomarkers of renal function (urea, BUN, creatinine, uric acid) and hepatic function (AST, ALT, ALP, bilirubin) were measured.
  • Redox status was assessed using lipid peroxidation (MDA), total thiols (TSH), and antioxidant potentials.
  • A cohort of 33 PE, 33 GDM, and 25 normal pregnancies (NP) was studied.

Main Results:

  • PE pregnancies showed significantly elevated urea, BUN, uric acid, creatinine, AST, ALT, and ALP compared to NP.
  • GDM pregnancies exhibited significant elevations in creatinine and ALT compared to NP.
  • Both PE and GDM groups displayed diminished antioxidant capacity, lower TSH, and increased MDA compared to NP.

Conclusions:

  • PE severely affects renal and hepatic functions, while GDM is associated with impaired liver and kidney performance.
  • An impaired redox state is implicated in the altered physiological processes observed in PE and GDM.
  • These findings support monitoring antioxidant status and may guide antioxidant supplementation in PE and GDM management.
Abstract

Keywords:
Gestational diabetes mellitusKidneyLiverOxidative stressPreeclampsiaPregnancy

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