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Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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Inflammatory Response01:28

Inflammatory Response

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An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
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B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

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The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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Regulation of the Unfolded Protein Response01:31

Regulation of the Unfolded Protein Response

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Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
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Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal01:22

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal

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Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
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Related Experiment Video

Updated: Nov 10, 2025

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

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Resolvin E1 Regulates Th17 Function and T Cell Activation.

Fatma Oner1,2, Carla Alvarez1,3, Wael Yaghmoor1,4

  • 1The Forsyth Institute, Cambridge, MA, United States.

Frontiers in Immunology
|April 5, 2021
PubMed
Summary
This summary is machine-generated.

Resolvin E1 (RvE1) reduces inflammation by inhibiting T helper 17 (Th17) cell activation and dendritic cell (DC) function. This specialized pro-resolving mediator restores immune homeostasis, offering potential therapeutic benefits for inflammatory diseases.

Keywords:
RvE1T cell - DC interactionsT helper (T) 17 cells Hresolution of inflammationresolvin

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Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation
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Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation

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Area of Science:

  • Immunology
  • Lipid mediators
  • Inflammation research

Background:

  • T helper 17 (Th17) cells mediate tissue destruction in chronic inflammatory diseases via IL-17.
  • Dendritic cells (DCs) drive Th17 responses through antigen presentation.
  • Resolvin E1 (RvE1) is a lipid mediator involved in inflammation resolution.

Purpose of the Study:

  • To investigate the potential of RvE1 in resolving inflammation by targeting Th17 cell function.
  • To elucidate the impact of RvE1 on Th17 differentiation and DC activity.
  • To explore RvE1's role in regulating immune responses.

Main Methods:

  • Assessed RvE1's effect on Th17 differentiation induced by IL-6/TGFβ.
  • Evaluated RvE1's impact on DC-stimulated Th17 differentiation in co-culture.
  • Measured RvE1's effect on DC maturation and pro-inflammatory cytokine production.

Main Results:

  • RvE1 inhibited Th17 differentiation markers (CD25, CCR6, IL-17).
  • RvE1 suppressed T cell activation and chemoattraction, reducing IL-17, IL-21, IL-10, and IL-2 production.
  • RvE1 limited DC activation and pro-inflammatory cytokine release.

Conclusions:

  • RvE1 effectively targets Th17 cell activation and dendritic cell function.
  • RvE1 demonstrates potential as a mechanism for inflammatory resolution.
  • RvE1 may modulate acquired immune responses to restore homeostasis.