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Fabrication of Three-dimensional Paper-based Microfluidic Devices for Immunoassays
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Functional paper-based materials for diagnostics.

Laura M Hillscher1,2, Valentina J Liebich3, Olga Avrutina3

  • 1Department of Macromolecular and Paper Chemistry, Technische Universität Darmstadt, 64287 Darmstadt, Germany.

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|April 5, 2021
PubMed
Summary
This summary is machine-generated.

Functional papers offer fast, inexpensive analyte detection and simplified lab work, crucial for medical diagnostics. This review explores their molecular basis, functionalization, and future research directions in paper-based assays.

Keywords:
Functional papersbiosensorcellulose functionalizationlateral flow assaypoint-of-care diagnosticsμPAD

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Area of Science:

  • Materials Science
  • Analytical Chemistry
  • Biotechnology

Background:

  • Functional papers are vital in modern society, enabling rapid and cost-effective analyte detection.
  • They significantly simplify laboratory procedures, particularly in medical testing applications.
  • Research in functional papers is driven by their versatility and broad applicability.

Purpose of the Study:

  • To provide a comprehensive overview of the molecular and structural fundamentals of functional papers.
  • To explore the diverse possibilities for paper functionalization in assay development.
  • To discuss commercially available paper-based assays, their production, and future research challenges.

Main Methods:

  • Review of scientific literature on paper science and functionalization techniques.
  • Analysis of the structural and molecular properties of cellulose-based materials.
  • Examination of existing commercial paper-based diagnostic assays and manufacturing processes.

Main Results:

  • Detailed explanation of paper's molecular structure and its impact on performance.
  • Overview of various chemical and physical methods for paper functionalization.
  • Discussion on the integration of paper substrates into commercially viable diagnostic tools.

Conclusions:

  • Functional papers represent a mature technology with ongoing innovation potential.
  • Further research is needed to address challenges in sensitivity, specificity, and large-scale production.
  • The field holds promise for advancing point-of-care diagnostics and other analytical applications.