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Color Spot Test As a Presumptive Tool for the Rapid Detection of Synthetic Cathinones
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Spot tests: past and present.

María Teresa Doménech-Carbó1, Antonio Doménech-Carbó2

  • 1Institut de Restauració del Patrimoni, Universitat Politècnica de València, Camí de Vera 14, 46022 Valencia, Spain.

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|January 3, 2022
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Summary
This summary is machine-generated.

Microchemistry, performing analyses on microgram scales, has evolved significantly since the 18th century. Modern spot tests, rooted in historical microchemistry, remain vital for diverse scientific applications today.

Keywords:
Chemical microscopyDipstick immunoassayELISALab-on-a-chipMicrochemistryMicrofluidicsMultiplexed testsSmartphone spectroscopySpot testsµPAD

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Area of Science:

  • Analytical Chemistry
  • Microscale Chemistry

Background:

  • Microchemistry, the chemistry of microgram quantities, originated in the late 18th and early 19th centuries.
  • Spot tests, a key microchemical technique, were widely developed in the early 20th century.
  • These methods are historically significant and remain relevant in modern scientific education and practice.

Purpose of the Study:

  • To provide a comprehensive overview of microchemistry and spot test analysis.
  • To trace the historical development and contemporary applications of this analytical methodology.

Main Methods:

  • Historical review of microchemical techniques and spot tests.
  • Analysis of the evolution of analytical methodologies at the microscale.

Main Results:

  • Spot tests, initially developed for didactic purposes, are crucial for applied analyses.
  • Microchemistry and spot tests are indispensable in fields such as cultural heritage conservation, food science, forensic science, clinical and pharmacological sciences, geochemistry, and environmental science.
  • Contemporary sophisticated applications include modern pregnancy and virus tests.

Conclusions:

  • Microchemistry and spot tests represent a long-standing yet continuously evolving field of analytical chemistry.
  • The historical foundations of microchemistry provide essential tools for a wide array of modern scientific and technological challenges.