Related Experiment Video

Updated: Nov 10, 2025

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
09:36

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device

Published on: September 24, 2020

2.9K

Drugs intervention study in COVID-19 management

Muhammad Taher1, Noratika Tik1, Deny Susanti2

  • 1Faculty of Pharmacy, International Islamic University Malaysia, Kuantan, Pahang, Malaysia.

Drug Metabolism and Personalized Therapy
|April 5, 2021
PubMed

Insights

This review identifies effective COVID-19 treatments. Remdesivir, ivermectin, hydroxychloroquine, favipiravir, corticosteroids, and convalescent plasma show therapeutic benefits for Coronavirus 2019 management.

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Critical Care Medicine

Background:

  • The Coronavirus (COVID-19) pandemic caused significant global mortality by February 2021.
  • Effective therapeutic interventions are crucial for managing COVID-19 and mitigating its impact.

Purpose of the Study:

  • To systematically review and identify potential therapeutic approaches and drugs for Coronavirus 2019 (COVID-19) management.
  • To evaluate the clinical evidence supporting various treatment options for COVID-19.

Main Methods:

  • A systematic scoping review of articles reporting clinical evidence for COVID-19 therapeutic management.
  • Searches were conducted across Google Scholar, PubMed, and Science Direct databases.
  • 31 articles were selected based on predefined inclusion and exclusion criteria.

Main Results:

  • Remdesivir and ivermectin demonstrated significant reduction in viral ribonucleic acid (RNA) activity.
  • Convalescent plasma (CP) significantly improved clinical symptoms in COVID-19 patients.
  • Corticosteroids increased survival rates in patients with acute respiratory distress syndrome (ARDS).
  • Hydroxychloroquine and favipiravir showed effectiveness against SARS-CoV-2.
  • Lopinavir-ritonavir combination was found ineffective.
  • Ribavirin, galidesivir, and sofosbuvir showed potential but lacked robust clinical evidence.

Conclusions:

  • Remdesivir, ivermectin, favipiravir, hydroxychloroquine, dexamethasone, methylprednisolone, and convalescent plasma are identified as potentially valuable therapeutic agents for COVID-19 management.
  • Further clinical evidence is needed for agents like ribavirin, galidesivir, and sofosbuvir.
  • The findings provide insights into current therapeutic strategies for COVID-19.
Keywords:
COVID-19SARS-CoV-2antiviralclinical trialdrug intervention

More Related Videos

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects05:46

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects

Published on: May 4, 2021

5.4K
An Educational Video Demonstration of How to Prone a Critically Ill Intubated Patient07:16

An Educational Video Demonstration of How to Prone a Critically Ill Intubated Patient

Published on: November 30, 2022

3.9K

Related Concept Videos

Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
75
Controls in Experiments01:13

Controls in Experiments

When conducting an experiment, it is crucial to have control to reduce bias and accurately measure the dependent variables. It also marks the results more reliable. Controls are elements in an experiment that have the same characteristics as the treatment groups but are not affected by the independent variable. By sorting these data into control and experimental conditions, the relationship between the dependent and independent variables can be drawn. A randomized experiment always includes a...
14.3K
Therapeutic Drug Monitoring: Affecting Factors01:29

Therapeutic Drug Monitoring: Affecting Factors

Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
55
Pneumonia IV: Management01:28

Pneumonia IV: Management

The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
554
Chronic Obstructive Pulmonary Disease-V: Management01:29

Chronic Obstructive Pulmonary Disease-V: Management

Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation
2.8K
Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
714