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Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness
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The 2017 ACC/AHA stage 1 hypertension is associated with arterial stiffness: a prospective analysis

Shanshan Liu1,2, Shujing Wu1,2, Jingya Niu1,2

  • 1Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Aging
|April 5, 2021
PubMed

Insights

Stage 1 hypertension, as defined by the 2017 ACC/AHA guidelines, significantly increases the risk of developing arterial stiffness. This association was particularly strong in younger adults and linked to systolic blood pressure levels.

Area of Science:

  • Cardiovascular Medicine
  • Hypertension Research
  • Vascular Biology

Background:

  • Arterial stiffness is a key indicator of cardiovascular risk.
  • The 2017 American College of Cardiology and American Heart Association (ACC/AHA) guideline provides updated definitions for hypertension stages.
  • Understanding the implications of stage 1 hypertension on vascular health is crucial for early intervention.

Purpose of the Study:

  • To investigate the association between stage 1 hypertension, according to the 2017 ACC/AHA guideline, and the subsequent development of arterial stiffness.
  • To evaluate if baseline stage 1 hypertension predicts future arterial stiffness in adults without pre-existing cardiovascular disease.

Main Methods:

  • A cohort of 4595 adults (aged ≥40 years) without cardiovascular disease were followed from 2010-2015 for a median of 4.3 years.
  • Blood pressure was categorized into normal, elevated, stage 1 hypertension, and stage 2 hypertension.
  • Arterial stiffness was defined by the development of increased brachial-ankle pulse wave velocity (ba-PWV) from a normal baseline.

Main Results:

  • Participants with stage 1 hypertension exhibited a 1.48-fold increased risk of developing arterial stiffness compared to those with normal blood pressure (OR=2.48, 95% CI=1.59-3.85).
  • The risk was more pronounced in adults aged 40-59 years (OR=4.08) than in those aged ≥60 years (OR=1.47).
  • Systolic blood pressure between 130-139 mmHg was independently associated with arterial stiffness (OR=2.90).

Conclusions:

  • The 2017 ACC/AHA classification of stage 1 hypertension is significantly linked to an elevated risk of developing arterial stiffness.
  • These findings highlight the importance of managing stage 1 hypertension to prevent vascular complications.
Abstract

Keywords:
2017 ACC/AHA guidelinearterial stiffnesscohortstage 1 hypertension

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