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Related Experiment Video

Updated: Nov 10, 2025

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test
06:35

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

Published on: April 27, 2016

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Restoring the endothelial barrier function in the elderly.

Nektarios Barabutis1, Mohammad S Akhter1, Khadeja-Tul Kubra1

  • 1School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA 71201, USA.

Mechanisms of Ageing and Development
|April 5, 2021
PubMed
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Elderly endothelial barrier dysfunction contributes to severe diseases like ARDS, sepsis, and COVID-19. This opinion discusses new therapeutic strategies to combat these conditions.

Area of Science:

  • Gerontology
  • Vascular Biology
  • Immunology

Background:

  • Endothelial barrier dysfunction is a key factor in severe diseases affecting the elderly.
  • Conditions like acute respiratory distress syndrome (ARDS), sepsis, and COVID-19 are linked to impaired endothelial function in older adults.

Purpose of the Study:

  • To present an opinion on novel therapeutic approaches targeting endothelial barrier dysfunction in the elderly.
  • To explore alternative strategies to counteract the pathogenesis of age-related severe disorders.

Main Methods:

  • This study is an opinion piece, synthesizing existing knowledge and expert perspectives.
  • It involves a critical review of current understanding of endothelial dysfunction and potential therapeutic interventions.
Keywords:
Acute lung injuryAcute respiratory distress syndromeInflammation

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Related Experiment Videos

Last Updated: Nov 10, 2025

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test
06:35

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

Published on: April 27, 2016

18.1K
Using En Face Immunofluorescence Staining to Observe Vascular Endothelial Cells Directly
06:09

Using En Face Immunofluorescence Staining to Observe Vascular Endothelial Cells Directly

Published on: August 20, 2019

16.2K
Assessing Endothelial Vasodilator Function with the Endo-PAT 2000
07:46

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

Published on: October 15, 2010

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Main Results:

  • The opinion highlights the critical role of endothelial barrier integrity in age-related disease severity.
  • It emphasizes the need for innovative therapeutic avenues beyond conventional treatments.

Conclusions:

  • Developing targeted therapies for endothelial dysfunction in the elderly is crucial for managing severe diseases.
  • Further research into alternative therapeutic strategies holds promise for improving outcomes in aging populations.