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Updated: Nov 10, 2025

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Feedback-controlled microbubble generator producing one million monodisperse bubbles per second.

Benjamin van Elburg1, Gonzalo Collado-Lara1, Gert-Wim Bruggert1

  • 1Physics of Fluids Group, Technical Medical (TechMed) Center and MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.

The Review of Scientific Instruments
|April 6, 2021
PubMed
Summary
This summary is machine-generated.

We developed a lab-on-a-chip instrument for producing highly uniform lipid-coated microbubbles. This technology enables precise control over microbubble size and production rate for advanced ultrasound imaging and therapy applications.

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Area of Science:

  • Biomedical Engineering
  • Microfluidics
  • Nanotechnology

Background:

  • Monodisperse lipid-coated microbubbles are crucial for advanced ultrasound contrast agents.
  • Existing methods face challenges in production rate and size control.

Purpose of the Study:

  • To present a novel lab-on-a-chip instrument for high-throughput, monodisperse microbubble generation.
  • To demonstrate real-time feedback control for precise microbubble size and production rate management.

Main Methods:

  • Development of a stand-alone microfluidic device.
  • Integration of an optical transmission-based measurement technique for real-time monitoring.
  • Implementation of a feedback loop for automated control of bubble radius and production rate.

Main Results:

  • Achieved high monodispersity in microbubble production at rates up to 10^6 bubbles/s.
  • Demonstrated precise control over on-chip bubble radii from 2.5 μm to 20 μm.
  • Observed bubble size stabilization post-formation without compromising monodispersity.

Conclusions:

  • The developed instrument offers stable, controlled, and safe operation for microbubble generation.
  • The feedback control system provides precise management of microbubble size distribution.
  • This technology facilitates the development of microfluidic platforms for non-specialist users and enhances ultrasound agent applications.