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Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions
Published on: January 20, 2022
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Sweet systems: technologies for glycomic analysis and their integration into systems biology
Shuhui Chen1, Rui Qin2, Lara K Mahal1,2
1Department of Chemistry, New York University, New York City, NY, USA.
Critical Reviews in Biochemistry and Molecular Biology
|April 6, 2021
Summary
Glycans are vital molecules altered in diseases like cancer. High-throughput glycomic technologies and systems biology approaches are advancing disease mechanism understanding and therapeutic development.
Area of Science:
- Biochemistry and Molecular Biology
- Systems Biology
- Glycoscience
Background:
- Glycans are ubiquitous molecules crucial for biological processes.
- Altered glycan composition (glycome) is linked to various diseases, including cancer and metabolic disorders.
- Studying glycosylation and glycomic changes offers insights into disease mechanisms and therapeutic strategies.
Purpose of the Study:
- To review analytical methods for high-throughput glycomic analysis.
- To highlight the integration of glycomics with systems biology for disease research.
- To showcase the role of glycomics in understanding disease progression and developing therapeutics.
Main Methods:
- Mass spectrometry for glycan structure determination.
- Liquid chromatography for glycan separation and analysis.
- Lectin microarrays for high-throughput glycan profiling.
Main Results:
- High-throughput technologies enable rapid and comprehensive glycomic analysis.
- Integration with systems biology enhances understanding of glycomics in disease.
- Representative studies demonstrate the utility of integrated glycomics approaches.
Conclusions:
- Advances in glycomic technologies are overcoming structural diversity challenges.
- Glycomics is increasingly integrated into systems biology for disease insights.
- Glycomics plays a pivotal role in advancing our understanding of disease and developing novel therapeutics.
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