Related Experiment Video
Updated: Nov 10, 2025
10:04
Enhancing Tumor Content through Tumor Macrodissection
Published on: February 12, 2022
11.3K
Diffuse large B-cell lymphoma: new targets and novel therapies
Bruce D Cheson1, Grzegorz Nowakowski2, Gilles Salles3
1Lymphoma Research Foundation, New York, NY, USA. bdcheson@gmail.com.
Blood Cancer Journal
|April 6, 2021
Summary
New therapies are needed for diffuse large B-cell lymphoma (DLBCL). Approved and emerging treatments, including targeted therapies and CAR-T cells, offer new hope for B-cell malignancy patients.
Area of Science:
- Hematology
- Oncology
- Immunotherapy
Background:
- Diffuse large B-cell lymphoma (DLBCL) and other B-cell malignancies require novel, non-cytotoxic treatments.
- Current treatment options have limitations, highlighting an unmet clinical need.
Purpose of the Study:
- To review recent advancements in therapies for B-cell malignancies.
- To discuss the potential of emerging targeted therapies and immunotherapies.
Main Methods:
- Literature review of recently approved and investigational agents for B-cell malignancies.
- Analysis of current treatment landscape, including targeted therapies, antibody-drug conjugates, bispecific antibodies, and CAR-T cell therapies.
Main Results:
- Several new agents are approved, including polatuzumab, selinexor, and tafasitamab.
- Three chimeric antigen receptor T-cell (CAR-T) therapies are FDA-approved, with more in development.
- Bispecific antibodies and antibody-drug conjugates represent promising future therapeutic avenues.
Conclusions:
- Combinations of targeted therapies are expected to improve outcomes for patients with B-cell malignancies.
- The evolving landscape of novel agents offers significant potential for enhanced patient care.
Related Concept Videos
02:57Targeted Cancer Therapies
8.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
8.0K
01:27Tumor Immunotherapy
816
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
816
01:24B Cell Activation and Differentiation
14.9K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
14.9K
02:56Treatment Resistant Cancers
3.5K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.5K
01:18Lymphoid Cells and Tissues
2.2K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
2.2K
01:16Primary Lymphoid Organs
13.3K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
13.3K