Related Experiment Video
Updated: Nov 10, 2025

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism
Published on: February 14, 2022
Investigating the effect of materials and structures for negative pressure ventilators suitable for pandemic
Nada Abughanam1, Shahd Sameer Mohammed Gaben1, Muhammad E H Chowdhury1
1Department of Electrical Engineering, Qatar University, Doha, 2713 Qatar.
Abstract:
The onset of the corona virus disease 2019 (COVID-19) pandemic caused shortages in mechanical ventilators (MVs) essential for the intensive care unit (ICU) in the hospitals. The increasing crisis prompted the investigation of ventilators which is low cost and offers lower health complications. Many researchers are revisiting the use of negative pressure ventilators (NPVs), due to the cost and complications of positive pressure ventilators (PPVs). This paper summarizes the evolution of the MVs, highlighting the limitations of popular positive and negative pressure ventilators and how NPV can be a cost-effective and lower health complication solution. This paper also provides a detailed investigation of the structure and material for the patient enclosure that can be used for a cost-effective NPV system using ANSYS simulations. The simulation results can confirm the selection and also help in developing a low cost while based on readily available materials. This can help the manufacturer to develop low-cost NPV and reduce the pressure on the healthcare system for any pandemic situation similar to COVID-19.
Related Concept Videos
Mechanical Ventilation II: Invasive Ventilation
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
Mechanical Ventilation I: Indication and Settings
Mechanical Ventilation III: Noninvasive Ventilation
Noninvasive Positive-Pressure Ventilation...
Transmission-based Precautions II: Airborne and Protective Environment
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
Ventilatory Modes
There are three ventilatory modes: full support, partial support, and spontaneous. These are described below.
Full Support Modes
Full support modes include controlled mechanical ventilation, continuous mandatory...
Factors Affecting Pulmonary Ventilation
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...

