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Single-step calculation of susceptibility through multiple orientation sampling.

Lin Chen1,2,3, Shuhui Cai1, Peter C M van Zijl2,3

  • 1Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, Xiamen University, Xiamen, China.

NMR in Biomedicine
|April 6, 2021
PubMed
Summary
This summary is machine-generated.

Single-step COSMOS (SSCOSMOS) offers improved quantitative susceptibility mapping (QSM) by integrating background field removal and dipole inversion. This novel method outperforms traditional multistep approaches, providing more accurate susceptibility quantification without complex parameter tuning.

Keywords:
calculation of susceptibility through multiple orientation sampling, ill-posed inversion, quantitative susceptibility mapping, single step, spherical mean value

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Area of Science:

  • Medical Imaging
  • Biophysics
  • Computational Science

Background:

  • Quantitative susceptibility mapping (QSM) estimates magnetic susceptibility from MR signal phase.
  • QSM inversion is ill-posed, requiring stabilization via regularization or oversampling.
  • Conventional COSMOS (multistep) involves sequential phase processing, risking error propagation.

Purpose of the Study:

  • To assess the feasibility of single-step COSMOS (SSCOSMOS) for integrated background field removal and dipole inversion using multiple orientations.
  • To establish SSCOSMOS as a potential gold standard for evaluating single-step QSM methods.

Main Methods:

  • Incorporated multiple spherical mean value (SMV) kernels of varying radii into the SSCOSMOS dipole inversion.
  • Compared SSCOSMOS reconstructions against multistep COSMOS (MSCOSMOS) using numerical head phantoms and in vivo human brain data.

Main Results:

  • SSCOSMOS enabled integrated background removal and dipole inversion without regularization parameter adjustments.
  • SSCOSMOS demonstrated superior performance over MSCOSMOS in simulations, yielding better susceptibility quantification and reduced reconstruction error.
  • Consistent tissue susceptibility values were achieved between SSCOSMOS and MSCOSMOS.

Conclusions:

  • SSCOSMOS is a feasible and effective method for quantitative susceptibility mapping.
  • The integrated approach of SSCOSMOS mitigates error propagation inherent in multistep methods.
  • SSCOSMOS provides a robust and potentially superior alternative to conventional COSMOS for QSM.