Related Experiment Video
Updated: Nov 10, 2025
07:24
Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos
Published on: December 13, 2018
6.6K
ADAMTS9-AS2: A Functional Long Non-coding RNA in Tumorigenesis
Wen Xu1, Bei Wang1, Yuxuan Cai1
1College of Medical Science, China Three Gorges University, Yichang 443002, China.
Current Pharmaceutical Design
|April 7, 2021
Summary
Long non-coding RNA ADAMTS9-AS2 plays a key role in cancer development by influencing cell proliferation, invasion, and apoptosis. This lncRNA shows promise as a diagnostic biomarker and therapeutic target for various human cancers.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Long non-coding RNAs (lncRNAs) are emerging as critical regulators in cancer biology.
- LncRNA ADAMTS9-AS2 has been implicated in various cancer processes.
- Understanding its molecular mechanisms is crucial for cancer research.
Purpose of the Study:
- To review and summarize the molecular mechanisms of lncRNA ADAMTS9-AS2 in human cancers.
- To highlight the role of ADAMTS9-AS2 in cancer occurrence and progression.
- To consolidate current knowledge on ADAMTS9-AS2's functions in oncology.
Main Methods:
- Systematic literature search of PubMed database.
- Inductive summarization of research findings.
- Focus on molecular mechanisms mediated by lncRNA ADAMTS9-AS2 in cancer.
Main Results:
- Aberrant expression of ADAMTS9-AS2 correlates with cancer proliferation, invasion, migration, and apoptosis inhibition.
- ADAMTS9-AS2 is involved in DNA methylation and PI3K/Akt/mTOR signaling pathways.
- It also regulates microRNAs (miRNAs) and protein expression in cancer cells.
Conclusions:
- LncRNA ADAMTS9-AS2 demonstrates significant potential as a therapeutic target for cancer.
- ADAMTS9-AS2 can serve as a promising biomarker for human cancer diagnosis and prognosis.
Related Concept Videos
02:39lncRNA - Long Non-coding RNAs
9.3K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.3K
02:39lncRNA - Long Non-coding RNAs
3.1K
3.1K
03:18Non-LTR Retrotransposons
12.5K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
12.5K
01:32RNA Splicing
58.5K
Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
58.5K
02:18Alternative RNA Splicing
23.6K
Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
23.6K
02:23Abnormal Proliferation
4.8K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.8K