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ADAMTS9-AS2: A Functional Long Non-coding RNA in Tumorigenesis

Wen Xu1, Bei Wang1, Yuxuan Cai1

  • 1College of Medical Science, China Three Gorges University, Yichang 443002, China.

Current Pharmaceutical Design
|April 7, 2021
PubMed
Abstract

Insights

Long non-coding RNA ADAMTS9-AS2 plays a key role in cancer development by influencing cell proliferation, invasion, and apoptosis. This lncRNA shows promise as a diagnostic biomarker and therapeutic target for various human cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Long non-coding RNAs (lncRNAs) are emerging as critical regulators in cancer biology.
  • LncRNA ADAMTS9-AS2 has been implicated in various cancer processes.
  • Understanding its molecular mechanisms is crucial for cancer research.

Purpose of the Study:

  • To review and summarize the molecular mechanisms of lncRNA ADAMTS9-AS2 in human cancers.
  • To highlight the role of ADAMTS9-AS2 in cancer occurrence and progression.
  • To consolidate current knowledge on ADAMTS9-AS2's functions in oncology.

Main Methods:

  • Systematic literature search of PubMed database.
  • Inductive summarization of research findings.
  • Focus on molecular mechanisms mediated by lncRNA ADAMTS9-AS2 in cancer.

Main Results:

  • Aberrant expression of ADAMTS9-AS2 correlates with cancer proliferation, invasion, migration, and apoptosis inhibition.
  • ADAMTS9-AS2 is involved in DNA methylation and PI3K/Akt/mTOR signaling pathways.
  • It also regulates microRNAs (miRNAs) and protein expression in cancer cells.

Conclusions:

  • LncRNA ADAMTS9-AS2 demonstrates significant potential as a therapeutic target for cancer.
  • ADAMTS9-AS2 can serve as a promising biomarker for human cancer diagnosis and prognosis.
Keywords:
ADAMTS9-AS2DNA methylationLong non-coding RNAmalignant tumorsmediating PI3K.therapeutic targets

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