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Cue Exposure Triggers Inhibitory Deficits in Individuals With Methamphetamine Use Disorder

Xi He1,2, Di Zhao3, Mingming Zhang1,2

  • 1Research Center of Brain and Cognitive Neuroscience, Liaoning Normal University, Dalian 116029, China.

Journal of Studies on Alcohol and Drugs
|April 7, 2021
PubMed
Abstract

Insights

Abstinent individuals with methamphetamine use disorder (MUD) show increased impulsivity when exposed to drug cues. This suggests drug cues impair inhibitory control during abstinence.

Area of Science:

  • Neuroscience
  • Psychology
  • Addiction Research

Background:

  • Inhibitory deficits are linked to impulsive drug-seeking in methamphetamine use disorder (MUD).
  • The impact of drug-associated cues on cognitive disinhibition in abstinent MUD individuals requires further investigation.

Purpose of the Study:

  • To evaluate the effect of drug-associated cue exposure on cognitive disinhibition in abstinent men with MUD.
  • To assess the utility of a novel go/no-go task in identifying impulsivity in this population.

Main Methods:

  • Recruited 54 abstinent men with MUD and 46 healthy controls (HC).
  • Administered a novel go/no-go task with 240 drug-associated cue trials.
  • Compared commission errors and reaction times between groups under different cue conditions.

Main Results:

  • Abstinent MUD group showed significantly more commission errors with drug cues compared to HC (p < .001).
  • No significant difference in commission errors between groups when cues were absent (p = .336).
  • MUD group exhibited shorter reaction times than HCs across all trials (p = .004).

Conclusions:

  • A novel go/no-go task effectively detects impulsivity in abstinent MUD individuals.
  • Drug-associated cue exposure demonstrably impairs inhibitory control in individuals with MUD during abstinence.

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