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Updated: Nov 10, 2025

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis

Published on: June 14, 2019

Does HPV Subtype Predict Outcomes in Head and Neck Cancers?

Hedyeh Ziai¹, Andrew Warner², Neil Mundi¹

¹Department of Otolaryngology-Head and Neck Surgery, Western University, ON, Canada.

International Journal of Otolaryngology

|April 7, 2021

Summary

This study found that human papillomavirus (HPV) genotypes other than HPV-16 in head and neck cancers were associated with better survival. Further research is needed to confirm these findings in larger patient cohorts.

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Area of Science:

Oncology
Virology
Genetics

Background:

The Cancer Genome Atlas (TCGA) study indicated that non-HPV-16 genotypes in head and neck cancers are linked to poorer survival.
This study investigates the association between specific HPV subtypes and patient survival outcomes in a large institutional cohort.

Purpose of the Study:

To analyze the correlation between HPV subtypes and survival rates in head and neck squamous cell carcinomas (HNSCC).
To compare survival outcomes for HPV-16 positive, other HPV positive, and HPV negative HNSCC cases.

Main Methods:

Collection of fresh frozen primary tumor biopsy samples and associated clinical data (demographics, staging, survival).
HPV subtyping using quantitative polymerase chain reaction (qPCR).
Statistical analysis employing univariable and multivariable Cox proportional hazards regression models.

Main Results:

Out of 280 patients, 30% had HPV-positive disease. Patients with p16-positive disease showed significantly improved 5-year overall survival (OS) and progression-free survival (PFS).
HPV-positive disease correlated with improved 5-year OS and PFS compared to HPV-negative disease, though not reaching statistical significance in this cohort.
Interestingly, patients with HPV-16 positive tumors trended towards worse 5-year OS and PFS compared to those with other HPV genotypes.

Conclusions:

Contrary to previous TCGA findings, this study suggests HPV-16 positive tumors may have inferior survival outcomes compared to tumors with other HPV genotypes.
Larger, multi-institutional studies are warranted to elucidate the prognostic significance of various HPV genotypes in HNSCC.