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Longitudinal Observation of Border Tissue Configuration During Axial Elongation in Childhood

Yong Woo Kim1, Jin Ju Choi2, Michael J A Girard3,4

  • 1Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

Investigative Ophthalmology & Visual Science
|April 7, 2021
PubMed

Insights

Childhood axial elongation involves changes in temporal border tissue and optic nerve head structures. These alterations, including Bruch

Area of Science:

  • Ophthalmology
  • Optometry
  • Pediatric Eye Research

Background:

  • Axial elongation is a key factor in refractive development during childhood.
  • Understanding changes in the optic nerve head and surrounding tissues is crucial for monitoring eye health.
  • Previous studies have not fully elucidated the dynamic changes in border tissue configuration during axial elongation.

Purpose of the Study:

  • To investigate the dynamic changes in border tissue configuration during axial elongation in childhood.
  • To correlate these structural changes with axial length changes in pediatric eyes.

Main Methods:

  • Fifty-four children (108 eyes) with serial swept-source optical coherence tomography scans were analyzed.
  • Eyes were classified into stable axial length (AXL) and elongating AXL groups.
  • Measurements included border tissue angle (BTA), Bruch's membrane opening distance (BMOD), and minimum rim width (MRW) in temporal and nasal regions.

Main Results:

  • Significant axial elongation occurred over 15.6 months.
  • Temporal border tissue angle changes correlated with AXL changes in elongating eyes.
  • Bruch's membrane opening distance and nasal minimum rim width increased significantly and correlated with AXL changes in elongating eyes.

Conclusions:

  • Axial elongation in childhood is associated with significant changes in temporal border tissue configuration.
  • Optic nerve head enlargement (BMO) and nasal peripapillary tissue elevation are correlated with axial length changes.
  • These findings highlight the dynamic structural adaptations of the optic nerve head during pediatric eye growth.
Abstract

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