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Updated: Nov 9, 2025

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Published on: November 17, 2010
Ocular Adverse Events following Yellow Fever Vaccination: A Case Series
Renato Rodrigues Pereima1, Rodolfo Bonatti1, Fernanda Crotti2
1Department of Ophthalmology-LIM33, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Purpose:
To describe four cases of ocular adverse events resembling intraocular inflammatory and non-inflammatory conditions following yellow fever vaccination (YFV) during a recent yellow fever (YF) outbreak in Brazil.
Methods:
Charts of patients diagnosed with ocular adverse events after YFV between January 2017 and January 2019 at two tertiary referral centers in Brazil.
Results:
Four patients (two adults and two children) are reported. Case 1 presented with typical findings of central serous chorioretinopathy which resolved spontaneously; case 2 was diagnosed with acute Vogt-Koyanagi-Harada disease; cases 3 and 4 had bilateral diffuse retinal vasculitis. In the absence of infectious and noninfectious disorders, the temporal association between stand-alone YFV and onset of ocular symptoms within 15 days was interpreted as evidence of causation.
Conclusions:
Clinicians should be aware of the wide spectrum of possible ocular adverse reactions to stand-alone YFV.
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