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AUGUR: a program to predict, display and analyze the tertiary structure of B-DNA
R K Tan1, M Prabhakaran, C S Tung
1Department of Biochemistry, University of Alabama, Birmingham 35294.
Computer Applications in the Biosciences : CABIOS
|March 1, 1988
Summary
AUGUR predicts and analyzes B-DNA's 3D structure using six models. This program generates and visualizes DNA trajectories, enabling searches for structural bends and homologues.
Area of Science:
- Structural Biology
- Bioinformatics
- Computational Chemistry
Background:
- Understanding the three-dimensional structure of Deoxyribonucleic Acid (DNA) is crucial for molecular biology.
- Predictive modeling aids in visualizing and analyzing DNA conformations.
Purpose of the Study:
- To introduce AUGUR, a software program designed for predicting, displaying, and analyzing the 3D structure of B-DNA.
- To provide tools for exploring DNA helical parameters and structural features.
Main Methods:
- Utilizes six distinct models to predict helical parameters for a given DNA sequence.
- Generates three-dimensional coordinates (trajectory) based on predicted helical parameters.
- Employs a graphics terminal for trajectory visualization and manipulation.
Main Results:
- Successfully predicts and visualizes B-DNA structures in 3D space.
- Enables interactive rotation and analysis of the generated DNA trajectory.
- Facilitates searching for structural bends and identifying homologous DNA structures.
Conclusions:
- AUGUR offers a comprehensive platform for B-DNA structure prediction and analysis.
- The software aids researchers in understanding DNA structural dynamics and identifying specific motifs.
- Provides valuable insights into DNA sequence-structure relationships.