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Multidisciplinary management of locally advanced pancreatic adenocarcinoma: Biology is King
Marc A Attiyeh1, Arya Amini2, Vincent Chung3
1Department of Surgical Oncology, City of Hope National Medical Center, Duarte, California, USA.
Abstract:
The annual incidence of pancreatic cancer is nearly 50,000 patients. The 5-year overall survival is only 9%, and there remains a great need for better therapy. A subset of these patients presents with locally advanced disease. Multidisciplinary therapy has evolved to include some combination of systemic chemotherapy, locoregional radiation, and surgery in select patients with excellent biology. This review will address the thoughtful evidence-based and individualized approach to these patients.
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